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Literature summary for 2.7.1.107 extracted from

  • Shulga, Y.V.; Loukov, D.; Ivanova, P.T.; Milne, S.B.; Myers, D.S.; Hatch, G.M.; Umeh, G.; Jalan, D.; Fullerton, M.D.; Steinberg, G.R.; Topham, M.K.; Brown, H.A.; Epand, R.M.
    Diacylglycerol kinase delta promotes lipogenesis (2013), Biochemistry, 52, 7766-7776.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine the isozyme DGKdelta may be a target for cancer chemotherapy Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
gene dgkdelta, both splicing variants delta1 and delta2 are recombinantly expressed as FLAG-tagged proteins in enzyme-deficient 3T3-L1 pre-adipocytes, real-time RT-PCR enzyme expression analysis during adipocyte differentiation shows that 3T3-L1 preadipocytes transfected with DGKdelta have no evidence of differentiation to adipocytes Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information generation of enzyme-deficient DGKdelta-KO mouse embryonic fibroblasts Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Mus musculus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1,2-diacyl-sn-glycerol Mus musculus
-
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
gene dgkdelta with two variants delta1 and delta2
-

Purification (Commentary)

Purification (Comment) Organism
recombinant FLAG-tagged splicing variants delta1 and delta2 from 3T3-L1 pre-adipocytes by affinity chromatography Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
brown adipose tissue DGKdelta is the most abundant isoform in murine brown adipose tissue Mus musculus
-
embryo
-
Mus musculus
-
fibroblast embryonic Mus musculus
-
heart DGKdelta is the most abundant isoform in murine heart tissue Mus musculus
-
liver DGKdelta and DGKtheta are the most abundant isoforms in murine liver Mus musculus
-
skeletal muscle DGKdelta and DGKzeta are the most abundant isoforms in murine muscle tissue Mus musculus
-
white adipose tissue DGKdelta is the most abundant isoform in murine white adipose tissue Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1,2-diacyl-sn-glycerol
-
Mus musculus ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
?

Synonyms

Synonyms Comment Organism
DGKdelta
-
Mus musculus
diacylglycerol kinase delta
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Mus musculus

General Information

General Information Comment Organism
malfunction transformed mouse embryo fibroblasts from mice that have a genetic deletion of DGKdelta exhibit decreased levels of many phospholipids and neutral lipids compared with wild-type mouse embryonic fibroblasts. DGKdelta knockout leads to down-regulation of enzymes responsible for fatty acid synthesis and lowers the amount of many lipid species within the cell Mus musculus
physiological function DGKdelta promotes de novo lipid synthesis is through signal transduction pathways, overview Mus musculus