Application | Comment | Organism |
---|---|---|
medicine | the isozyme DGKdelta may be a target for cancer chemotherapy | Mus musculus |
Cloned (Comment) | Organism |
---|---|
gene dgkdelta, both splicing variants delta1 and delta2 are recombinantly expressed as FLAG-tagged proteins in enzyme-deficient 3T3-L1 pre-adipocytes, real-time RT-PCR enzyme expression analysis during adipocyte differentiation shows that 3T3-L1 preadipocytes transfected with DGKdelta have no evidence of differentiation to adipocytes | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of enzyme-deficient DGKdelta-KO mouse embryonic fibroblasts | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Mus musculus | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1,2-diacyl-sn-glycerol | Mus musculus | - |
ADP + 1,2-diacyl-sn-glycerol 3-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
gene dgkdelta with two variants delta1 and delta2 | - |
Purification (Comment) | Organism |
---|---|
recombinant FLAG-tagged splicing variants delta1 and delta2 from 3T3-L1 pre-adipocytes by affinity chromatography | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brown adipose tissue | DGKdelta is the most abundant isoform in murine brown adipose tissue | Mus musculus | - |
embryo | - |
Mus musculus | - |
fibroblast | embryonic | Mus musculus | - |
heart | DGKdelta is the most abundant isoform in murine heart tissue | Mus musculus | - |
liver | DGKdelta and DGKtheta are the most abundant isoforms in murine liver | Mus musculus | - |
skeletal muscle | DGKdelta and DGKzeta are the most abundant isoforms in murine muscle tissue | Mus musculus | - |
white adipose tissue | DGKdelta is the most abundant isoform in murine white adipose tissue | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1,2-diacyl-sn-glycerol | - |
Mus musculus | ADP + 1,2-diacyl-sn-glycerol 3-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DGKdelta | - |
Mus musculus |
diacylglycerol kinase delta | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | transformed mouse embryo fibroblasts from mice that have a genetic deletion of DGKdelta exhibit decreased levels of many phospholipids and neutral lipids compared with wild-type mouse embryonic fibroblasts. DGKdelta knockout leads to down-regulation of enzymes responsible for fatty acid synthesis and lowers the amount of many lipid species within the cell | Mus musculus |
physiological function | DGKdelta promotes de novo lipid synthesis is through signal transduction pathways, overview | Mus musculus |