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Literature summary for 2.7.1.107 extracted from

  • Prodeus, A.; Berno, B.; Topham, M.K.; Epand, R.M.
    The basis of the substrate specificity of the epsilon isoform of human diacylglycerol kinase is not a consequence of competing hydrolysis of ATP (2013), Chem. Phys. Lipids, 166, 26-30.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens P52429 isoform diaclyglycerol kinase epsilon
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-stearoyl-2-arachidonoyl-sn-glycerol
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Homo sapiens ADP + 1-stearoyl-2-arachidonoyl-sn-glycerol 3-phosphate
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ATP + 1-stearoyl-2-linoleoyl-sn-glycerol
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Homo sapiens ADP + 1-stearoyl-2-linoleoyl-sn-glycerol 3-phosphate
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additional information water does not compete with diacylglycerol as an acceptor of the gamma-phosphate of ATP. Neither with the highly specific substrate, 1-stearoyl-2-arachidonoyl-sn-glycerol, nor with a less specific substrate, 1-stearoyl-2-linoleoyl-sn-glycerol, is there any evidence for ATP hydrolysis accompanying substrate phosphorylation Homo sapiens ?
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