Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.107 extracted from

  • Gantayet, A.; Jegatheswaran, J.; Jayakumaran, G.; Topham, M.K.; Epand, R.M.
    Endocannabinoids and diacylglycerol kinase activity (2011), Biochim. Biophys. Acta, 1808, 1050-1053.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine enzyme is able to remove 1-stearoyl-2-arachidonoylglycerol, the precursor of the endocannabinoid 2-arachidonoyl glycerol Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-arachidonoyl glycerol inhibitor for both of the epsilon or the zeta isoforms of diacylglycerol kinase; inhibitor for both of the epsilon or the zeta isoforms of diacylglycerol kinase Homo sapiens
2-oleoyl glycerol inhibits diacylglycerol kinase epsilon less than does 2-arachidonoyl glycerol; shows similar inhibitory potency for diacylglycerol kinase zeta as 2-arachidonoyl glycerol Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P52429 isoform diacylglycerolkinase epsilon
-
Homo sapiens Q13574 isoform diacylglycerolkinase zeta
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information 2-arachidonoyl glycerol is a very poor substrate for the epsilon isoform of diacylglycerol kinases. 2-Oleoyl glycerol is also a poor substrate for this isoform of diacylglycerol kinases Homo sapiens ?
-
?
additional information 2-arachidonoyl glycerol is a very poor substrate for the zeta isoforms of diacylglycerol kinases. 2-Oleoyl glycerol is also a poor substrate for this isoform Homo sapiens ?
-
?