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Literature summary for 2.7.1.107 extracted from

  • Gellett, A.M.; Kharel, Y.; Sunkara, M.; Morris, A.J.; Lynch, K.R.
    Biosynthesis of alkyl lysophosphatidic acid by diacylglycerol kinases (2012), Biochem. Biophys. Res. Commun., 422, 758-763.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
(S)-2-amino-2-((S)-6-octyl-1,2,3,4-tetrahydronaphthalen-2-yl)propan-1-ol analogue of FTY720, 0.01 mM increase phosphorylation of 1-O-hexadecyl-sn-2-acetyl glycerol by isoform diacylglycerol kinase alpha about 3.5fold. Homo sapiens
FTY720 in presence of 0.01 mM FTY720, phosphorylation of 1-O-hexadecyl-sn-2-acetyl glycerol by isoforms diacylglycerol kinase alpha, beta or gamma is 3fold increased Homo sapiens
sphingosine in presence of 0.01 mM sphingosine, phosphorylation of 1-O-hexadecyl-sn-2-acetyl glycerol by isoforms diacylglycerol kinase alpha, beta or gamma is 7-9fold increased Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell
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Homo sapiens
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SKOV-3 cell
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Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1,2-dioleoyl-sn-glycerol about 15fold the rate of 1-O-hexadecyl-sn-glycerol phosphorylation, isoforms diacylglycerol kinase alpha, beta, gamma, delta1, delta1, zeta, jota, theta Homo sapiens ADP + 1,2-dioleoyl-sn-glycerol 3-phosphate
-
?
ATP + 1-O-hexadecyl-2-sn-acetyl glycerol about 12fold the rate of 1-O-hexadecyl-sn-glycerol phosphorylation, isoforms diacylglycerol kinase alpha, beta, gamma, delta1, delta1, zeta, jota, theta Homo sapiens ADP + 1-O-hexadecyl-2-sn-acetyl glycerol 3-phosphate
-
?
ATP + 1-O-hexadecyl-sn-glycerol
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Homo sapiens ADP + 1-O-hexadecyl-sn-glycerol 3-phosphate
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?
additional information alkyl-lysophosphatidic acid can be produced in SKOV-3 cells by diacylglycerol kinase-mediated phosphorylation of 1-O-hexadecyl-sn-2-acetyl glycerol followed by deacetylation of 1-O-hexadecyl-sn-2-acetyl glycerol 3-phosphate. Production of alkyl-lysophosphatidic acid is stimulated by sphingosine and its analogues Homo sapiens ?
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?

General Information

General Information Comment Organism
physiological function treating SKOV-3 ovarian cancer cell with a sphingosine analogue stimulates conversion of exogenous 1-alkyl-2-acetyl glycerol to alkyl-lysophosphatidic acid. Diacylglycerol kinase alpha may contribute significantly to the production of alkyl-lysophosphatidic acid in SKOV-3 cells, showing cross-talk between the sphingolipid and glycerol lipid pathways Homo sapiens