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Literature summary for 2.7.1.107 extracted from

  • Yasuda, S.; Kai, M.; Imai, S.; Takeishi, K.; Taketomi, A.; Toyota, M.; Kanoh, H.; Sakane, F.
    Diacylglycerol kinase eta augments C-Raf activity and B-Raf/C-Raf heterodimerization (2009), J. Biol. Chem., 284, 29559-29570.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
G392D activity of the mutant is less than 1% of the wild type enzyme Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q86XP1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1,2-diacylglycerol
-
Homo sapiens ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
?

Synonyms

Synonyms Comment Organism
DGKeta1 isoform Homo sapiens
DGKeta2 isoform Homo sapiens
diacylglycerol kinase eta isoform Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens

General Information

General Information Comment Organism
malfunction small interfering RNA-dependent knockdown of diacylglycerol kinase eta impairs the Ras/B-Raf/C-Raf/MEK/ERK pathway activated by epidermal growth factor in HeLa cells and inhibits cell proliferation Homo sapiens
physiological function overexpression of DGKeta1 can activate the Ras/B-Raf/C-Raf/MEK/ERK pathway in a DGK activity-independent manner, suggesting that DGKeta serves as a scaffold/adaptor protein, DGKeta activates C-Raf but not B-Raf Homo sapiens