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Literature summary for 2.7.1.107 extracted from

  • Kai, M.; Yasuda, S.; Imai, S.; Toyota, M.; Kanoh, H.; Sakane, F.
    Diacylglycerol kinase alpha enhances protein kinase Czeta-dependent phosphorylation at Ser311 of p65/RelA subunit of nuclear factor-kappaB (2009), FEBS Lett., 583, 3265-3268.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens
-
Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1,2-diacylglycerol Homo sapiens
-
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
?
ATP + 1,2-diacylglycerol Sus scrofa
-
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P23743
-
-
Sus scrofa P20192
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1,2-diacylglycerol
-
Homo sapiens ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
?
ATP + 1,2-diacylglycerol
-
Sus scrofa ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
?

Synonyms

Synonyms Comment Organism
DGKalpha
-
Homo sapiens
DGKalpha
-
Sus scrofa
diacylglycerol kinase alpha
-
Homo sapiens
diacylglycerol kinase alpha
-
Sus scrofa

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens
ATP
-
Sus scrofa

General Information

General Information Comment Organism
physiological function isoform DGKalpha positively regulates tumor nuclear factor-alpha-dependent necrosis factor-kappaB activation via the protein kinase Czeta-mediated Ser311 phosphorylation of p65/RelA, isoform DGKalpha does not affect phosphorylation of IkappaB, DGKalpha enhances phosphorylation of p65 at Ser311 but not at Ser468 or Ser536 Homo sapiens
physiological function isoform DGKalpha positively regulates tumor nuclear factor-alpha-dependent necrosis factor-kappaB activation via the protein kinase Czeta-mediated Ser311 phosphorylation of p65/RelA, isoform DGKalpha does not affect phosphorylation of IkappaB, DGKalpha enhances phosphorylation of p65 at Ser311 but not at Ser468 or Ser536 Sus scrofa