Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cAMP | stimulates nuclear diacylglycerol kinase catalytic activity | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | silencing of diacylglycerol kinase theta by siRNA expression inhibits cAMP-dependent CYP17 transcription. LXXLL motifs in diacylglycerol kinase theta mediate a direct interaction of steroidogenic factor 1 with the kinase and may facilitate binding of phosphatidic acid to the receptor | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
NCI-H295R cell | activation of the adrenocorticotropin/cAMP signal transduction cascade rapidly increases nuclear diacylglycerol kinase activity and phosphatidic acid production. LXXLL motifs in diacylglycerol kinase theta mediate a direct interaction of nuclear receptor steroidogenic factor 1 with the kinase and may facilitate binding of phosphatidic acid to the receptor | Homo sapiens | - |
Subunits | Comment | Organism |
---|---|---|
More | nuclear receptor steroidogenic factor 1 binds to diacylglycerol kinase zeta and diacylglycerol kinase theta in vitro and in vivo | Homo sapiens |