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BRENDA support

Literature summary for 2.7.1.107 extracted from

  • Li, D.; Urs, A.N.; Allegood, J.; Leon, A.; Merrill, A.H.; Sewer, M.B.
    Cyclic AMP-stimulated interaction between steroidogenic factor 1 and diacylglycerol kinase theta facilitates induction of CYP17 (2007), Mol. Cell. Biol., 27, 6669-6685.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
cAMP stimulates nuclear diacylglycerol kinase catalytic activity Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information silencing of diacylglycerol kinase theta by siRNA expression inhibits cAMP-dependent CYP17 transcription. LXXLL motifs in diacylglycerol kinase theta mediate a direct interaction of steroidogenic factor 1 with the kinase and may facilitate binding of phosphatidic acid to the receptor Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
NCI-H295R cell activation of the adrenocorticotropin/cAMP signal transduction cascade rapidly increases nuclear diacylglycerol kinase activity and phosphatidic acid production. LXXLL motifs in diacylglycerol kinase theta mediate a direct interaction of nuclear receptor steroidogenic factor 1 with the kinase and may facilitate binding of phosphatidic acid to the receptor Homo sapiens
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Subunits

Subunits Comment Organism
More nuclear receptor steroidogenic factor 1 binds to diacylglycerol kinase zeta and diacylglycerol kinase theta in vitro and in vivo Homo sapiens