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BRENDA support

Literature summary for 2.7.1.107 extracted from

  • Fogle, K.J.; Lyashchenko, A.K.; Turbendian, H.K.; Tibbs, G.R.
    HCN pacemaker channel activation is controlled by acidic lipids downstream of diacylglycerol kinase and phospholipase A2 (2007), J. Neurosci., 27, 2802-2814.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
4beta-phorbol-12-myristate-13-acetate enhances voltage-dependent opening of wild-type and cAMP/H+-uncoupled hyperpolarization activated, cyclic nucleotide-regulated channels. 4beta-Phorbol-12-myristate-13-acetate exerts its effects on channel gating via sequential activation ofprotein kinase C and diacylglycerol kinase coupled with upregulation of mitogen-activated protein kinase and phospholipase A2 Xenopus laevis

Organism

Organism UniProt Comment Textmining
Xenopus laevis Q7ZYJ3
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-

Source Tissue

Source Tissue Comment Organism Textmining
oocyte
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Xenopus laevis
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