Activating Compound | Comment | Organism | Structure |
---|---|---|---|
D-glucose | exposure of L6 cell myotubes overexpressing human insulin receptors to 25 mM glucose for 5 min decreases the intracellular levels of diacylglycerol, paralleled by transient activation of diacylglycerol kinase and of insulin receptor signaling. Following 30-min exposure, both diacylglycerol levels and diacylglycerol kinase activity return close to basal levels. Glucose exposure redistributes diacylglycerol kinase isoforms alpha and delta, from the prevalent cytosolic localization to the plasma membrane fraction | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | antisense silencing of diacylglacerol kinase isoform delta, but not alpha, expression is sufficient to prevent the effect of high glucose on protein kinase alpha activity, insulin receptor signaling, and glucose uptake | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
R59949 | inhibition of diacylglycerol kinase activity accompanied by increased protein kinase Calpha activity, reduced glucose-induced insulin receptor activation, and GLUT4 translocation. Inhibition of decrease in the intracellular levels of diacylglycerol upon exposure of L6 cells to glucose | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
L-6 myoblast cell | - |
Rattus norvegicus | - |