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Literature summary for 2.7.1.107 extracted from

  • Miele, C.; Paturzo, F.; Teperino, R.; Sakane, F.; Fiory, F.; Oriente, F.; Ungaro, P.; Valentino, R.; Beguinot, F.; Formisano, P.
    Glucose regulates diacylglycerol intracellular levels and protein kinase C activity by modulating diacylglycerol kinase subcellular localization (2007), J. Biol. Chem., 282, 31835-31843.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
D-glucose exposure of L6 cell myotubes overexpressing human insulin receptors to 25 mM glucose for 5 min decreases the intracellular levels of diacylglycerol, paralleled by transient activation of diacylglycerol kinase and of insulin receptor signaling. Following 30-min exposure, both diacylglycerol levels and diacylglycerol kinase activity return close to basal levels. Glucose exposure redistributes diacylglycerol kinase isoforms alpha and delta, from the prevalent cytosolic localization to the plasma membrane fraction Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information antisense silencing of diacylglacerol kinase isoform delta, but not alpha, expression is sufficient to prevent the effect of high glucose on protein kinase alpha activity, insulin receptor signaling, and glucose uptake Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
R59949 inhibition of diacylglycerol kinase activity accompanied by increased protein kinase Calpha activity, reduced glucose-induced insulin receptor activation, and GLUT4 translocation. Inhibition of decrease in the intracellular levels of diacylglycerol upon exposure of L6 cells to glucose Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
L-6 myoblast cell
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Rattus norvegicus
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