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Literature summary for 2.7.1.107 extracted from

  • Williams, J.M.; Pettitt, T.R.; Powell, W.; Grove, J.; Savage, C.O.; Wakelam, M.J.
    Antineutrophil cytoplasm antibody-stimulated neutrophil adhesion depends on diacylglycerol kinase-catalyzed phosphatidic acid formation (2007), J. Am. Soc. Nephrol., 18, 1112-1120.
    View publication on PubMed

Application

Application Comment Organism
medicine patients with certain forms of systematic vasculitis, such as Wegener’s granulomatosis, have circulating antineutrophil cytoplasmic antibodies. Diacylglycerol kinase is selectively activated by circulating antineutrophil cytoplasmic antibodies and the generated phosphatidic acid is responsible for promoting neutrophil adhesion, in part through integrin activation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
antineutrophil cytoplasmic antibody selective activation of diacylglycerol kinase Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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