Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.107 extracted from

  • Liu, C.H.; Machado, F.S.; Guo, R.; Nichols, K.E.; Burks, A.W.; Aliberti, J.C.; Zhong, X.P.
    Diacylglycerol kinase zeta regulates microbial recognition and host resistance to Toxoplasma gondii (2007), J. Exp. Med., 204, 781-792.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine deficiency for diacylglycerol kinase zeta results in impaired interleukin 12 and tumor necrosis factor alpha production following toll-like receptor stimulation in vitro and in vivo, increased resistance to endotoxin shock, and enhanced susceptibility to Toxoplasma gondii infection Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information deficiency for diacylglycerol kinase zeta results in impaired interleukin 12 and tumor necrosis factor alpha production following toll-like receptor stimulation in vitro and in vivo, increased resistance to endotoxin shock, and enhanced susceptibility to Toxoplasma gondii infection. Deficiency results in increased activation of the phosphatidylinositol 3-kinase-Akt pathway. Inhibition of phosphatidylinositol 3-kinase activity or treatment with phosphatidic acid can restore lipopolysaccharide-induced interleukin 12 production by diacylglycerol kinase zeta-deficient mice Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus diacylglycerol kinase zeta regulates microbial recognition and host resistance to Toxoplasma gondii ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus Q80UP3 diacylglycerol kinase zeta
-

Source Tissue

Source Tissue Comment Organism Textmining
dendritic cell
-
Mus musculus
-
macrophage
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information diacylglycerol kinase zeta regulates microbial recognition and host resistance to Toxoplasma gondii Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
DGKzeta
-
Mus musculus