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Literature summary for 2.7.1.107 extracted from

  • Evangelisti, C.; Tazzari, P.L.; Riccio, M.; Fiume, R.; Hozumi, Y.; fala, F.; Goto, K.; Manzoli, L.; Cocco, L.; Martelli, A.M.
    Nuclear diacylglycerol kinase-zeta is a negative regulator of cell cycle progression in C2C12 mouse myoblasts (2007), FASEB J., 21, 3297-3307.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information overexpression of diacylglycerol kinase zeta blocks cells in G1 phase of cell cycle. Cell cycle arrest is accompanied by decreased levels of retinoblastoma protein phosphorylated on Ser-807/811. Down-regulation by siRNA increases the number of cells in both the S and G2/M phases of the cell cycle and prevents the cell cycle block characterizing C2C12 cell myogenic differentiation Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Mus musculus 5634
-
nucleus involvement of isoform diacylglycerol kinase zeta in cell-cycle progression Mus musculus 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus nuclear diacylglycerol kinase-zeta is a negative regulator of cell cycle progression in C2C12 mouse myoblasts ?
-
?
additional information Mus musculus diacylglycerol kinase zeta is a key determinant of cell cycle progression and differentiation of C2C12 cells ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus Q80UP3
-
-

Source Tissue

Source Tissue Comment Organism Textmining
C2C12 cell
-
Mus musculus
-
C2C12 cell nuclear diacylglycerol kinase-zeta is a negative regulator of cell cycle progression in C2C12 mouse myoblasts Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information nuclear diacylglycerol kinase-zeta is a negative regulator of cell cycle progression in C2C12 mouse myoblasts Mus musculus ?
-
?
additional information diacylglycerol kinase zeta is a key determinant of cell cycle progression and differentiation of C2C12 cells Mus musculus ?
-
?