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Literature summary for 2.7.1.107 extracted from

  • Alonso, R.; Mazzeo, C.; Merida, I.; Izquierdo, M.
    : A new role of diacylglycerol kinase alpha on the secretion of lethal exosomes bearing Fas ligand during activation-induced cell death of T lymphocytes (2007), Biochimie, 89, 213-221.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
R59949 pre-treatment increases both carbamoylcholine-induced and phytohemagglutinin-induced apoptosis due to an increase in the release of exosomes bearing non-processed pro-apoptotic protein FasL Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endosome
-
Homo sapiens 5768
-
exosome
-
Homo sapiens
-
-
Golgi apparatus trans-Golgi network Homo sapiens 5794
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme plays a role in the secretion of lethal exosomes bearing Fas ligand during activation-induced cell death of T lymphocytes ?
-
?
additional information Homo sapiens diacylglycerol kinase alpha is involved in secretion of pro-apoptotic protein Fas ligand by T-lymphocytes via the regulation of the release of lethal exosomes by the exocytic pathway ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens P23743
-
-

Source Tissue

Source Tissue Comment Organism Textmining
JURKAT cell
-
Homo sapiens
-
JURKAT cell DGKalpha expression in T cells inhibits secretion of FasL-bearing exosomes triggered by receptor stimulation, and subsequent acivation-induced cell death is impaired. Conversely, the inhibition of DGKalpha enhances the secretion of these lethal exosomes carrying mFasL and enhances acivation-induced cell death Homo sapiens
-
T-lymphocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme plays a role in the secretion of lethal exosomes bearing Fas ligand during activation-induced cell death of T lymphocytes Homo sapiens ?
-
?
additional information diacylglycerol kinase alpha is involved in secretion of pro-apoptotic protein Fas ligand by T-lymphocytes via the regulation of the release of lethal exosomes by the exocytic pathway Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
DGKalpha
-
Homo sapiens
diacylglycerol kinase alpha
-
Homo sapiens