Inhibitors | Comment | Organism | Structure |
---|---|---|---|
R59949 | pre-treatment increases both carbamoylcholine-induced and phytohemagglutinin-induced apoptosis due to an increase in the release of exosomes bearing non-processed pro-apoptotic protein FasL | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endosome | - |
Homo sapiens | 5768 | - |
exosome | - |
Homo sapiens | - |
- |
Golgi apparatus | trans-Golgi network | Homo sapiens | 5794 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme plays a role in the secretion of lethal exosomes bearing Fas ligand during activation-induced cell death of T lymphocytes | ? | - |
? | |
additional information | Homo sapiens | diacylglycerol kinase alpha is involved in secretion of pro-apoptotic protein Fas ligand by T-lymphocytes via the regulation of the release of lethal exosomes by the exocytic pathway | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | P23743 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
JURKAT cell | - |
Homo sapiens | - |
JURKAT cell | DGKalpha expression in T cells inhibits secretion of FasL-bearing exosomes triggered by receptor stimulation, and subsequent acivation-induced cell death is impaired. Conversely, the inhibition of DGKalpha enhances the secretion of these lethal exosomes carrying mFasL and enhances acivation-induced cell death | Homo sapiens | - |
T-lymphocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme plays a role in the secretion of lethal exosomes bearing Fas ligand during activation-induced cell death of T lymphocytes | Homo sapiens | ? | - |
? | |
additional information | diacylglycerol kinase alpha is involved in secretion of pro-apoptotic protein Fas ligand by T-lymphocytes via the regulation of the release of lethal exosomes by the exocytic pathway | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DGKalpha | - |
Homo sapiens |
diacylglycerol kinase alpha | - |
Homo sapiens |