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Literature summary for 2.7.1.107 extracted from

  • Los, A.P.; de Widt, J.; Topham, M.K.; van Blitterswijk, W.J.; Divecha, N.
    Protein kinase C inhibits binding of diacylglycerol kinase-zeta to the retinoblastoma protein (2007), Biochim. Biophys. Acta, 1773, 352-357.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in COS-7 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
S258D/S265D/S270D/S271D mutation in diacylglycerol kinase zeta for mimicking of protein kinase C phosphorylation of serine residues within the MARCKS phosphorylation site domain. Mutations do prevent binding to retinoblastoma protein Homo sapiens
S258N/S265N/S270N/S271N mutation in diacylglycerol kinase zeta for mimicking of protein kinase C phosphorylation of serine residues within the MARCKS phosphorylation site domain. Mutations do not prevent binding to retinoblastoma protein and subsequent stimulation of activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
phorbol ester activation of protein kinase C which inhibits diacylglycerol kinase epsilon binding to retinoblastoma protein. Mimicking of protein kinase C phosphorylation of serine residues by S/D mutations but not S/N mutations within the MARCKS phosphorylation site domain also prevents binding to retinoblastoma protein Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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