Cloned (Comment) | Organism |
---|---|
expression in COS-7 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
S258D/S265D/S270D/S271D | mutation in diacylglycerol kinase zeta for mimicking of protein kinase C phosphorylation of serine residues within the MARCKS phosphorylation site domain. Mutations do prevent binding to retinoblastoma protein | Homo sapiens |
S258N/S265N/S270N/S271N | mutation in diacylglycerol kinase zeta for mimicking of protein kinase C phosphorylation of serine residues within the MARCKS phosphorylation site domain. Mutations do not prevent binding to retinoblastoma protein and subsequent stimulation of activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
phorbol ester | activation of protein kinase C which inhibits diacylglycerol kinase epsilon binding to retinoblastoma protein. Mimicking of protein kinase C phosphorylation of serine residues by S/D mutations but not S/N mutations within the MARCKS phosphorylation site domain also prevents binding to retinoblastoma protein | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |