Activating Compound | Comment | Organism | Structure |
---|---|---|---|
phosphatidic acid | more effective activator than phosphatidylserine. Phosphatidic acid decreases the apparent surface KM of DGKtheta for dioleoylglycerol and promotes binding to vesicles in a dose-dependent manner | Homo sapiens | |
phosphatidic acid | phosphatidic acid is more effective than phosphatidiylserine. Both decreases the apparent surface KM value for dioleoylglycerol and promote binding to vesicles, but through different mechanisms | Homo sapiens | |
phosphatidylserine | less effective activator than phosphatidic acid. Phosphatidylserine decreases the apparent surface KM of DGKtheta for dioleoylglycerol | Homo sapiens | |
phosphatidylserine | phosphatidic acid is more effective than phosphatidiylserine. Both decreases the apparent surface KM value for dioleoylglycerol and promote binding to vesicles, but through different mechanisms | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression in IIC9 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
alpha-thrombin | apparent binding parameters of diacylglycerol kinase theta increase following alpha-thrombin stimulation | Homo sapiens | |
thrombin | stimulation results in an increase in the apparent KM of DGKtheta at low concentrations of substrate dioleoylglycerol. Increasing the bulk concentration of dioleoylglycerol returns the apparent KM to the basal value | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | KMapp for substrate 1,2-dioleoyl-sn-glycerol is 0.9 mol% in presence of 1% phosphatidic acid, 0.6 mol% in presence of 9% phosphatidylserine, and 8.0 mol% without additive | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1,2-dioleoyl-sn-glycerol | - |
Homo sapiens | ADP + 1,2-dioleoyl-sn-glycerol 3-phosphate | - |
? |