Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.107 extracted from

  • Luo, B.; Regier, D.S.; Prescott, S.M.; Topham, M.K.
    Diacylglycerol kinases (2004), Cell. Signal., 16, 983-989.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information serotonin signalling activates the enzyme Caenorhabditis elegans

Cloned(Commentary)

Cloned (Comment) Organism
-
Drosophila melanogaster
-
Mammalia
-
Arabidopsis thaliana
-
Caenorhabditis elegans
expression of the isolated catalytic subunit of isozyme alpha shows 60% of maximal wild-type full length enzyme activity Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information mutation of the second glycine in the binding sequence motif GXGXXG of the ATP-binding site to aspartate or alanine renders the mutant enzymes catalytically inactive Mammalia
additional information mutation of the second glycine in the binding sequence motif GXGXXG of the ATP-binding site to aspartate or alanine renders the mutant enzymes catalytically inactive Homo sapiens
additional information the ATP binding sequence of isozyme DGK2in strain rdgA contains the mutant GXDXXG motif leading to rapid retinal degeneration after birth Drosophila melanogaster

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Drosophila melanogaster 5829
-
cytosol
-
Mammalia 5829
-
cytosol
-
Homo sapiens 5829
-
cytosol
-
Arabidopsis thaliana 5829
-
cytosol
-
Caenorhabditis elegans 5829
-
membrane
-
Drosophila melanogaster 16020
-
membrane
-
Arabidopsis thaliana 16020
-
membrane
-
Caenorhabditis elegans 16020
-
additional information subcellular localization of isozymes, overview, the enzyme must undergo membrane translocation for access of diacylglycerols Drosophila melanogaster
-
-
additional information subcellular localization of isozymes, overview, the enzyme must undergo membrane translocation for access of diacylglycerols Mammalia
-
-
additional information subcellular localization of isozymes, overview, the enzyme must undergo membrane translocation for access of diacylglycerols Homo sapiens
-
-
additional information subcellular localization of isozymes, overview, the enzyme must undergo membrane translocation for access of diacylglycerols Arabidopsis thaliana
-
-
additional information subcellular localization of isozymes, overview, the enzyme must undergo membrane translocation for access of diacylglycerols Caenorhabditis elegans
-
-
perinuclear space
-
Mammalia
-
-
perinuclear space
-
Homo sapiens
-
-
plasma membrane isozyme alpha Mammalia 5886
-
plasma membrane isozyme alpha Homo sapiens 5886
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Drosophila melanogaster
Mg2+
-
Mammalia
Mg2+
-
Homo sapiens
Mg2+
-
Arabidopsis thaliana
Mg2+
-
Caenorhabditis elegans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1,2-diacylglycerol Drosophila melanogaster the enzyme binds and regulates signalling proteins which are activated by either diacylglycerol or phosphatidic acid ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
?
ATP + 1,2-diacylglycerol Mammalia the enzyme binds and regulates signalling proteins which are activated by either diacylglycerol or phosphatidic acid ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
?
ATP + 1,2-diacylglycerol Homo sapiens the enzyme binds and regulates signalling proteins which are activated by either diacylglycerol or phosphatidic acid ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
?
ATP + 1,2-diacylglycerol Arabidopsis thaliana the enzyme binds and regulates signalling proteins which are activated by either diacylglycerol or phosphatidic acid ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
?
ATP + 1,2-diacylglycerol Caenorhabditis elegans the enzyme binds and regulates signalling proteins which are activated by either diacylglycerol or phosphatidic acid, isozyme dgk-1 regulates diacylglycerol signalling required for acetylcholine release ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
?
additional information Mammalia complex enzyme regulation involving alternative splicing, overview, the enzyme is involved in several processes such as cell growth, neuronal transmission, and cytoskeleton remodeling ?
-
?
additional information Drosophila melanogaster complex enzyme regulation, overview, the enzyme is involved in several processes such as cell growth, neuronal transmission, and cytoskeleton remodeling ?
-
?
additional information Arabidopsis thaliana complex enzyme regulation, overview, the enzyme is involved in several processes such as cell growth, neuronal transmission, and cytoskeleton remodeling ?
-
?
additional information Caenorhabditis elegans complex enzyme regulation, overview, the enzyme is involved in several processes such as cell growth, neuronal transmission, and cytoskeleton remodeling ?
-
?
additional information Homo sapiens the isozyme zeta interacts with phosphoinositol phosphate 5-kinase activating it via phosphatidic acid, isozyme theta associates with RhoA, complex enzyme regulation involving alternative splicing, overview, the enzyme is involved in several processes such as cell growth, neuronal transmission, and cytoskeleton remodeling ?
-
?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-
Caenorhabditis elegans
-
-
-
Drosophila melanogaster
-
-
-
Homo sapiens
-
9 different isozymes divided into 5 subtypes, alternative splicing of isozymes
-
Mammalia
-
9 different isozymes divided into 5 subtypes, alternative splicing of isozymes
-
no activity in Saccharomyces cerevisiae
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
T-lymphocyte
-
Mammalia
-
T-lymphocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1,2-diacylglycerol
-
Drosophila melanogaster ADP + 1,2-diacyl-sn-glycerol 3-phosphate i.e. phosphatidic acid ?
ATP + 1,2-diacylglycerol
-
Mammalia ADP + 1,2-diacyl-sn-glycerol 3-phosphate i.e. phosphatidic acid ?
ATP + 1,2-diacylglycerol
-
Homo sapiens ADP + 1,2-diacyl-sn-glycerol 3-phosphate i.e. phosphatidic acid ?
ATP + 1,2-diacylglycerol
-
Arabidopsis thaliana ADP + 1,2-diacyl-sn-glycerol 3-phosphate i.e. phosphatidic acid ?
ATP + 1,2-diacylglycerol
-
Caenorhabditis elegans ADP + 1,2-diacyl-sn-glycerol 3-phosphate i.e. phosphatidic acid ?
ATP + 1,2-diacylglycerol the enzyme binds and regulates signalling proteins which are activated by either diacylglycerol or phosphatidic acid Drosophila melanogaster ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
?
ATP + 1,2-diacylglycerol the enzyme binds and regulates signalling proteins which are activated by either diacylglycerol or phosphatidic acid Mammalia ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
?
ATP + 1,2-diacylglycerol the enzyme binds and regulates signalling proteins which are activated by either diacylglycerol or phosphatidic acid Homo sapiens ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
?
ATP + 1,2-diacylglycerol the enzyme binds and regulates signalling proteins which are activated by either diacylglycerol or phosphatidic acid Arabidopsis thaliana ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
?
ATP + 1,2-diacylglycerol the enzyme binds and regulates signalling proteins which are activated by either diacylglycerol or phosphatidic acid, isozyme dgk-1 regulates diacylglycerol signalling required for acetylcholine release Caenorhabditis elegans ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
?
additional information complex enzyme regulation involving alternative splicing, overview, the enzyme is involved in several processes such as cell growth, neuronal transmission, and cytoskeleton remodeling Mammalia ?
-
?
additional information complex enzyme regulation, overview, the enzyme is involved in several processes such as cell growth, neuronal transmission, and cytoskeleton remodeling Drosophila melanogaster ?
-
?
additional information complex enzyme regulation, overview, the enzyme is involved in several processes such as cell growth, neuronal transmission, and cytoskeleton remodeling Arabidopsis thaliana ?
-
?
additional information complex enzyme regulation, overview, the enzyme is involved in several processes such as cell growth, neuronal transmission, and cytoskeleton remodeling Caenorhabditis elegans ?
-
?
additional information the isozyme zeta interacts with phosphoinositol phosphate 5-kinase activating it via phosphatidic acid, isozyme theta associates with RhoA, complex enzyme regulation involving alternative splicing, overview, the enzyme is involved in several processes such as cell growth, neuronal transmission, and cytoskeleton remodeling Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
More structure-function relationships of isozyme domain motifs, e.g. the C1 domain, the EF hand, and the pleckstrin homology, structural motifs and their organization, mammalian isozymes require other domain in addition to the catalytic domain for activity, overview Mammalia
More structure-function relationships of isozyme domain motifs, e.g. the C1 domain, the EF hand, and the pleckstrin homology, structural motifs and their organization, mammalian isozymes require other domain in addition to the catalytic domain for activity, overview Homo sapiens
More structure-function relationships of isozyme domain motifs, overview Drosophila melanogaster
More structure-function relationships of isozyme domain motifs, overview Arabidopsis thaliana
More structure-function relationships of isozyme domain motifs, overview Caenorhabditis elegans

Synonyms

Synonyms Comment Organism
DGK
-
Drosophila melanogaster
DGK
-
Mammalia
DGK
-
Homo sapiens
DGK
-
Arabidopsis thaliana
DGK
-
Caenorhabditis elegans

Cofactor

Cofactor Comment Organism Structure
ATP
-
Arabidopsis thaliana
ATP
-
Caenorhabditis elegans
ATP the binding sequence contains the GXGXXG motif essential for activity Drosophila melanogaster
ATP the binding sequence contains the GXGXXG motif essential for activity Mammalia
ATP the binding sequence contains the GXGXXG motif essential for activity Homo sapiens