Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | addition of cholesterol and/or phosphatidylethanolamine reduce the substrate specificity | Mammalia |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | Km values of isozymes DGKzeta, DGKepsilon, and DGKalpha with different substrates in mol% | Mammalia |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Mammalia | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | dependent on, maximal below 0.01 mM | Mammalia | |
Mg2+ | - |
Mammalia | |
additional information | effects of liposome composition on substrate specificity and catalytic activity level of the isozymes | Mammalia |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1,2-diacylglycerol | Mammalia | - |
ADP + 1,2-diacyl-sn-glycerol 3-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mammalia | - |
9 different isozymes | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | tissue-specific expression of isozymes | Mammalia | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
activity measurment of enzyme solubilized in liposomes consisting different amounts of 1,2-dioleoylphosphatidylcholine, 1,2-dioleoylphosphatidylethanolamine, and 1,2-dioleoylphosphatidylserine, overview | Mammalia |
0.0002 | 0.018 | substrate specificity and catalytic activity level of the isozymes at different liposome compositions | Mammalia |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + 1,2-diacylglycerol | - |
Mammalia | ADP + 1,2-diacyl-sn-glycerol 3-phosphate | - |
? | |
ATP + 1,2-dioleoyl-sn-glycerol | - |
Mammalia | ADP + 1,2-dioleoyl-sn-glycerol 3-phosphate | - |
? | |
ATP + 1-O-hexanoyl-2-arachidonoyl-sn-glycerol | preferred by isozyme DGKzeta and isozyme DGKalpha | Mammalia | ADP + 1-O-hexanoyl-2-arachidonoyl-sn-glycerol 3-phosphate | - |
? | |
ATP + 1-O-hexanoyl-2-oleoyl-sn-glycerol | - |
Mammalia | ADP + 1-O-hexanoyl-2-oleoyl-sn-glycerol 3-phosphate | - |
? | |
ATP + 1-stearoyl-2-arachidonoyl-sn-glycerol | - |
Mammalia | ADP + 1-stearoyl-2-arachidonoyl-sn-glycerol 3-phosphate | - |
? | |
additional information | isozymes DGKzeta, DGKalpha, and DGKepsilon utilize 1-alkyl-2-acyl-glycerols as substrates, addition of cholesterol and/or phosphatidylethanolamine reduce the substrate specificity | Mammalia | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DGK | - |
Mammalia |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Mammalia |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | 8 | assay at | Mammalia |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mammalia |