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Literature summary for 2.7.1.107 extracted from

  • Epand, R.M.; Kam, A.; Bridgelal, N.; Saiga, A.; Topham, M.K.
    The alpha isoform of diacylglycerol kinase exhibits arachidonoyl specificity with alkylacylglycerol (2004), Biochemistry, 43, 14778-14783.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information addition of cholesterol and/or phosphatidylethanolamine reduce the substrate specificity Mammalia

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information Km values of isozymes DGKzeta, DGKepsilon, and DGKalpha with different substrates in mol% Mammalia

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Mammalia 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ dependent on, maximal below 0.01 mM Mammalia
Mg2+
-
Mammalia
additional information effects of liposome composition on substrate specificity and catalytic activity level of the isozymes Mammalia

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1,2-diacylglycerol Mammalia
-
ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Mammalia
-
9 different isozymes
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information tissue-specific expression of isozymes Mammalia
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
activity measurment of enzyme solubilized in liposomes consisting different amounts of 1,2-dioleoylphosphatidylcholine, 1,2-dioleoylphosphatidylethanolamine, and 1,2-dioleoylphosphatidylserine, overview Mammalia
0.0002 0.018 substrate specificity and catalytic activity level of the isozymes at different liposome compositions Mammalia

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1,2-diacylglycerol
-
Mammalia ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
?
ATP + 1,2-dioleoyl-sn-glycerol
-
Mammalia ADP + 1,2-dioleoyl-sn-glycerol 3-phosphate
-
?
ATP + 1-O-hexanoyl-2-arachidonoyl-sn-glycerol preferred by isozyme DGKzeta and isozyme DGKalpha Mammalia ADP + 1-O-hexanoyl-2-arachidonoyl-sn-glycerol 3-phosphate
-
?
ATP + 1-O-hexanoyl-2-oleoyl-sn-glycerol
-
Mammalia ADP + 1-O-hexanoyl-2-oleoyl-sn-glycerol 3-phosphate
-
?
ATP + 1-stearoyl-2-arachidonoyl-sn-glycerol
-
Mammalia ADP + 1-stearoyl-2-arachidonoyl-sn-glycerol 3-phosphate
-
?
additional information isozymes DGKzeta, DGKalpha, and DGKepsilon utilize 1-alkyl-2-acyl-glycerols as substrates, addition of cholesterol and/or phosphatidylethanolamine reduce the substrate specificity Mammalia ?
-
?

Synonyms

Synonyms Comment Organism
DGK
-
Mammalia

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Mammalia

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5 8 assay at Mammalia

Cofactor

Cofactor Comment Organism Structure
ATP
-
Mammalia