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Literature summary for 2.7.1.107 extracted from

  • Badola, P.; Sanders, C.R.2nd.
    Escherichia coli diacylglycerol kinase is an evolutionarily optimized membrane enzyme and catalyzes direct phosphoryl transfer (1997), J. Biol. Chem., 272, 24176-24182.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
adenosine 5'-tetraphosphoryl-3-O-(1,2-dihexanoyl)-sn-glycerol
-
Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1
-
ADP about, pH 6.8, 30°C, reaction with sn-2,3-dihexanoylglycerol Escherichia coli
2.6
-
ATP pH 6.8, 30°C, reaction with sn-2,3-dihexanoylglycerol Escherichia coli
4.2
-
2'-deoxy-ATP pH 6.8, 30°C, reaction with sn-2,3-dihexanoylglycerol Escherichia coli
5.9
-
ITP pH 6.8, 30°C, reaction with sn-2,3-dihexanoylglycerol Escherichia coli
8.7
-
GTP pH 6.8, 30°C, reaction with sn-2,3-dihexanoylglycerol Escherichia coli

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Escherichia coli 16020
-

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Escherichia coli

Reaction

Reaction Comment Organism Reaction ID
ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate random equilibrium mechanism Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2'-deoxy-ATP + sn-1,2-dihexanoylglycerol
-
Escherichia coli 2'-deoxy-ADP + sn-1,2-dihexanoylglycerol 3-phosphate
-
?
ADP + sn-1,2-dihexanoylglycerol MgADP- is a very poor phosphoryl donor Escherichia coli AMP + sn-1,2-dihexanoylglycerol 3-phosphate
-
?
ATP + sn-1,2-dihexanoylglycerol
-
Escherichia coli ADP + sn-1,2-dihexanoylglycerol 3-phosphate
-
?
GTP + sn-1,2-dihexanoylglycerol
-
Escherichia coli GDP + sn-1,2-dihexanoylglycerol 3-phosphate
-
?
ITP + sn-1,2-dihexanoylglycerol
-
Escherichia coli IDP + sn-1,2-dihexanoylglycerol 3-phosphate
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information Ki-value for adenosine 5'-tetraphosphoryl-3-O-(1,2-dihexanoyl)-sn-glycerol is 0.036 mol% Escherichia coli