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Literature summary for 2.7.1.107 extracted from

  • Bunting, M.; Tang, W.; Zimmerman, G.A.; McIntyre, T.M.; Prescott, S.M.
    Molecular cloning and characterization of a novel human diacylglycerol kinase zeta (1996), J. Biol. Chem., 271, 10230-10236.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
COS-7 cells transfected with DGKksi cDNA express a 117000 Da and a 114000 Da protein. The transfected cells also express increased diacylglycerol kinase activity, which is not altered in the presence of R59949 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zinc the enzyme contains two zinc fingers Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
103900
-
x * 103900, calculation from nucleotide sequence Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q13574
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain DGKksi mRNA is expressed at high level Homo sapiens
-
endothelium
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1,2-dicapryl-sn-glycerol about 140% of the activity with sn-1,2-dioleoylglycerol Homo sapiens ADP + 1,2-dicapryl-sn-glycerol 3-phosphate
-
?
ATP + 1-oleoyl-2-palmitoyl-sn-glycerol about 85% of the activity with sn-1,2-dioleoylglycerol, DGKksi Homo sapiens ADP + 1-palmitoyl-2-oleoyl-sn-glycerol 3-phosphate
-
?
ATP + 1-palmitoyl-2-oleoyl-sn-glycerol about 80% of the activity with sn-1,2-dioleoylglycerol Homo sapiens ADP + 1-palmitoyl-2-oleoyl-sn-glycerol 3-phosphate
-
?
ATP + 1-palmitoyl-2-oleoyl-sn-glycerol about 80% of the activity with sn-1,2-dioleoylglycerol, DGKksi Homo sapiens ADP + 1-palmitoyl-2-oleoyl-sn-glycerol 3-phosphate
-
?
ATP + 1-stearoyl-2-arachidonoyl-sn-glycerol 108% of the activity with sn-1,2-dioleoylglycerol Homo sapiens ADP + 1-stearoyl-2-arachidonoyl-sn-glycerol 3-phosphate
-
?
ATP + sn-1,2-dioleoylglycerol recombinant DGKksi Homo sapiens ADP + sn-1,2-dioleoylglycerol 3-phosphate
-
?
ATP + sn-1,3-dioleoylglycerol about 10% of the activity with sn-1,2-dioleoylglycerol Homo sapiens ADP + ?
-
?

Subunits

Subunits Comment Organism
? x * 103900, calculation from nucleotide sequence Homo sapiens