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Literature summary for 2.7.1.107 extracted from

  • Outram, S.V.; Crompton, T.; Merida, I.; Varas, A.; Martinez, A.C.
    Diacylglycerol kinase alpha activity promotes survival of CD4+ 8+ double positive cells during thymocyte development (2002), Immunology, 105, 391-398.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
R59949 DGKalpha Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1,2-diacyl-sn-glycerol Mus musculus high level expression of DGKalpha is induced following a signal transmitted through the pre-T-cell-receptor and the protein tyrosine kinase lck. Activity of DGKalpha contributes to survival in CD4+ 8+ double positive thymocytes as pharmacological inhibition of DGK activity results in death of this cell population both in cell suspension and thymic explants. DGKalpha promotes survival in theses thymocytes through a Bcl-regulated pathway ADP + 1,2-diacyl-sn-glycerol 3-phosphate
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Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
brain DGKalpha Mus musculus
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T-cell DGKalpha Mus musculus
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thymocyte DGKalpha Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1,2-diacyl-sn-glycerol high level expression of DGKalpha is induced following a signal transmitted through the pre-T-cell-receptor and the protein tyrosine kinase lck. Activity of DGKalpha contributes to survival in CD4+ 8+ double positive thymocytes as pharmacological inhibition of DGK activity results in death of this cell population both in cell suspension and thymic explants. DGKalpha promotes survival in theses thymocytes through a Bcl-regulated pathway Mus musculus ADP + 1,2-diacyl-sn-glycerol 3-phosphate
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