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Literature summary for 2.7.1.107 extracted from

  • Walsh, J.P.; Bell, R.M.
    sn-1,2-Diacylglycerol kinase of Escherichia coli. Structural and kinetic analysis of the lipid cofactor dependence (1986), J. Biol. Chem., 261, 15062-15069.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
1,3-dioleoylglycerol activates Escherichia coli
1-O-alkylphosphatidylcholine half-maximal activation at 21.9 mol% Escherichia coli
bis-phosphatidic acid half-maximal activation at 3.9 mol% Escherichia coli
cardiolipin mitochondrial, half-maximal activation at 2.3 mol% Escherichia coli
di-O-hexadecylphosphatidylcholine half-maximal activation at 13.5 mol% Escherichia coli
dilauroylphosphatidylcholine half-maximal activation at 11.9 mol% Escherichia coli
dimethylmyristamide activates Escherichia coli
dioleoyl ethylene glycol activates Escherichia coli
dioleoylphosphatidylcholine half-maximal activation at 10.4 mol% Escherichia coli
dioleoylphosphatidylglycerol half-maximal activation at 6.3 mol% Escherichia coli
hexadecanol activates Escherichia coli
hexadecyl phosphorylcholine half-maximal activation at 17.3 mol% Escherichia coli
methyl myristate activates Escherichia coli
myristoylcholine chloride activates Escherichia coli
myristyl acetate activates Escherichia coli
nitrododecane activates Escherichia coli
octyl acetate activates Escherichia coli
oleoylcholine chloride activates Escherichia coli
phosphatidylcholine plasmalogen half-maximal activation at 7.3 mol% Escherichia coli
phosphatidylserine activates Escherichia coli
platelet-activating factor half-maximal activation at 22.4 mol% Escherichia coli
rac-1,2-dioleoylglycero-3-sulfate half-maximal activation at 2.7 mol% Escherichia coli
sn-1,2-dioleoylglycerol activates Escherichia coli
sn-1,3-dioleoylglycerol activates Escherichia coli
sodium hexadecyl sulfate half-maximal activation at 9.8 mol% Escherichia coli
stearoyllysophosphatidylcholine half-maximal activation at 15.8 mol% Escherichia coli

General Stability

General Stability Organism
lipid activators stabilize the enzyme agisnt inactivation induced by diacylglycerol. Mg2+ and Mn2+ show only a small stabilization effect both in presence and in absence of 10 mol% phosphatidylglycerol Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + sn-1,2-dioctanoylglycerol
-
Escherichia coli ADP + sn-1,2-dioctanoylglycerol 3-phosphate
-
?
ATP + sn-1,2-dioleoylglycerol
-
Escherichia coli ADP + sn-1,2-dioleoylglycerol 3-phosphate
-
?
additional information sn-1,3-dioleoylglycerol is not a substrate Escherichia coli ?
-
?