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Literature summary for 2.7.1.107 extracted from

  • Walsh, J.P.; Bell, R.M.
    Diacylglycerol kinase from Escherichia coli (1992), Methods Enzymol., 209, 153-162.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
cholesterol 3-sulfate activates Escherichia coli
hexadecylphosphorylcholine activates Escherichia coli
Sodium dodecyl sulfate activates Escherichia coli
Triton X-100 activates Escherichia coli

General Stability

General Stability Organism
when cosolubilized with diacylglycerol in octylglucoside micelles, the enzyme undergoes rapid irreversible inactivation Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
Ca2+
-
Escherichia coli
diacylglycerol above 3.4 mol%, substrate inhibition Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information Km for dioleoylglycerol is 0.92 mol% Escherichia coli

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane tightly associated with the inner membrane Escherichia coli 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Cd2+ enzyme requires a free divalent metal cation: Mg2+, Mn2+, Co2+, Cd2+ or Zn2+ Escherichia coli
Co2+ enzyme requires a free divalent metal cation: Mg2+, Mn2+, Co2+, Cd2+ or Zn2+ Escherichia coli
Mg2+ enzyme requires a free divalent metal cation: Mg2+, Mn2+, Co2+, Cd2+ or Zn2+ Escherichia coli
Mn2+ enzyme requires a free divalent metal cation: Mg2+, Mn2+, Co2+, Cd2+ or Zn2+. Ka for Mg2+ is 3.4 mM Escherichia coli
Zn2+ enzyme requires a free divalent metal cation: Mg2+, Mn2+, Co2+, Cd2+ or Zn2+ Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1,2-diacyl-sn-glycerol Escherichia coli the enzyme functions to recycle diacylglycerol which is generated largely as a by-product of membrane-derived oligosaccharide biosynthesis ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1,2-diacyl-sn-glycerol the enzyme functions to recycle diacylglycerol which is generated largely as a by-product of membrane-derived oligosaccharide biosynthesis Escherichia coli ADP + 1,2-diacyl-sn-glycerol 3-phosphate
-
?
ATP + ceramide
-
Escherichia coli ADP + ceramide 3-phosphate
-
?
ATP + sn-1,2-dioleoylglycerol
-
Escherichia coli ADP + sn-1,2-dioleoylglycerol 3-phosphate
-
?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
additional information
-
addition of phospholipids provides some protection from thermal inactivation Escherichia coli
57
-
Triton-solubilized preparation, t1/2: 12 min Escherichia coli
100
-
enzyme activity of membranes, t1/2: 20 min Escherichia coli