BRENDA - Enzyme Database
show all sequences of 2.7.1.106

Inhibitors of glucose-1,6-bisphosphate synthase

Rose, I.A.; Warms, J.V.B.; Wong, L.J.; J. Biol. Chem. 252, 4262-4268 (1977)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
cis/trans-aconitate
-
Bos taurus
citrate
-
Bos taurus
D-fructose 1,6-diphosphate
-
Bos taurus
D-glucose 1,6-diphosphate
-
Bos taurus
Glutarate
weak
Bos taurus
glycerate 2,3-diphosphate
-
Bos taurus
Glycerate 3-phosphate
-
Bos taurus
isocitrate
-
Bos taurus
K+
weak
Bos taurus
L-malate
weak
Bos taurus
Li+
strong, dilution, Co2+ or Zn2+ protects, not Ca2+, Mg2+ or Mn2+
Bos taurus
additional information
no inhibition by adipate or succinate
Bos taurus
Na+
weak
Bos taurus
phosphate
-
Bos taurus
phosphoenolpyruvate
strong
Bos taurus
tricarballylate
-
Bos taurus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.000087
-
3-phospho-D-glyceroyl 1-phosphate
23C, pH 8, Mg2+-enzyme in brain
Bos taurus
0.000091
-
3-phospho-D-glyceroyl 1-phosphate
23C, pH 8, Zn2+-enzyme in brain
Bos taurus
0.09
-
D-glucose 1-phosphate
23C, pH 8, Mg2+- and Zn2+-enzyme in brain
Bos taurus
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Co2+
tightly bound, can replace Zn2+
Bos taurus
Mg2+
activation, easily dissociates from enzyme protein; Km-value: 1 mM; no activation of enzyme in Zn-form
Bos taurus
Zn2+
Zn-form of the enzyme: tightly bound, about 65% of brain enzyme in Zn-form
Bos taurus
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Bos taurus
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
brain
-
Bos taurus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate
-
640350
Bos taurus
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
-
-
-
r
Temperature Optimum [C]
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
25
-
assay at
Bos taurus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
cis/trans-aconitate
-
Bos taurus
citrate
-
Bos taurus
D-fructose 1,6-diphosphate
-
Bos taurus
D-glucose 1,6-diphosphate
-
Bos taurus
Glutarate
weak
Bos taurus
glycerate 2,3-diphosphate
-
Bos taurus
Glycerate 3-phosphate
-
Bos taurus
isocitrate
-
Bos taurus
K+
weak
Bos taurus
L-malate
weak
Bos taurus
Li+
strong, dilution, Co2+ or Zn2+ protects, not Ca2+, Mg2+ or Mn2+
Bos taurus
additional information
no inhibition by adipate or succinate
Bos taurus
Na+
weak
Bos taurus
phosphate
-
Bos taurus
phosphoenolpyruvate
strong
Bos taurus
tricarballylate
-
Bos taurus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.000087
-
3-phospho-D-glyceroyl 1-phosphate
23C, pH 8, Mg2+-enzyme in brain
Bos taurus
0.000091
-
3-phospho-D-glyceroyl 1-phosphate
23C, pH 8, Zn2+-enzyme in brain
Bos taurus
0.09
-
D-glucose 1-phosphate
23C, pH 8, Mg2+- and Zn2+-enzyme in brain
Bos taurus
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Co2+
tightly bound, can replace Zn2+
Bos taurus
Mg2+
activation, easily dissociates from enzyme protein; Km-value: 1 mM; no activation of enzyme in Zn-form
Bos taurus
Zn2+
Zn-form of the enzyme: tightly bound, about 65% of brain enzyme in Zn-form
Bos taurus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
brain
-
Bos taurus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate
-
640350
Bos taurus
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
-
-
-
r
Temperature Optimum [C] (protein specific)
Temperature Optimum [C]
Temperature Optimum Maximum [C]
Commentary
Organism
25
-
assay at
Bos taurus
Other publictions for EC 2.7.1.106
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
674867
Maliekal
Molecular identification of ma ...
Homo sapiens
J. Biol. Chem.
282
31844-31851
2007
-
-
1
-
-
-
3
-
-
-
-
-
-
3
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640349
Ueda
Regulation of glucose 1,6-bisp ...
Bos taurus
J. Biochem.
83
1721-1730
1978
-
-
-
-
-
-
3
8
1
1
-
1
-
1
-
-
1
-
-
2
2
-
6
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
8
1
1
-
1
-
-
-
1
-
2
2
-
6
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
640350
Rose
Inhibitors of glucose-1,6-bisp ...
Bos taurus
J. Biol. Chem.
252
4262-4268
1977
-
-
-
-
-
-
16
3
-
3
-
-
-
1
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
16
-
3
-
3
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
640348
Rose
A specific enzyme for glucose ...
Mus musculus
J. Biol. Chem.
250
3466-3470
1975
-
-
-
-
-
-
8
-
1
7
-
1
-
1
-
-
1
-
-
1
-
-
7
-
1
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
8
-
-
1
7
-
1
-
-
-
1
-
1
-
-
7
-
1
-
-
-
1
1
-
-
-
-
-
-
-
-