BRENDA - Enzyme Database show
show all sequences of 2.7.1.106

Regulation of glucose 1,6-bisphosphate level in liver. III. Purification and properties of bovine glucose 1,6-bisphosphate synthase

Ueda, M.; Hirose, M.; Sasaki, R.; Chiba, H.; J. Biochem. 83, 1721-1730 (1978)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
D-fructose 1,6-diphosphate
strong, liver
Bos taurus
glycerate 2,3-diphosphate
strong, liver
Bos taurus
phosphoenolpyruvate
strong
Bos taurus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.00023
-
3-phospho-D-glyceroyl 1-phosphate
25°C, pH 7.5, liver enzyme peak I
Bos taurus
0.00028
-
3-phospho-D-glyceroyl 1-phosphate
25°C, pH 7.5, liver enzyme peak II
Bos taurus
0.00045
-
3-phospho-D-glyceroyl 1-phosphate
25°C, pH 7.5, erythrocyte enzyme
Bos taurus
0.009
-
D-glucose 1-phosphate
25°C, pH 7.5, liver enzyme peak I
Bos taurus
0.015
-
D-glucose 6-phosphate
25°C, pH 7.5, liver enzyme peak I
Bos taurus
0.059
-
D-glucose 1-phosphate
25°C, pH 7.5, liver enzyme peak II
Bos taurus
0.061
-
D-glucose 6-phosphate
25°C, pH 7.5, liver enzyme peak II
Bos taurus
0.16
-
D-glucose 1-phosphate
25°C, pH 7.5, erythrocyte enzyme
Bos taurus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
soluble
-
Bos taurus
-
-
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Mg2+
-
Bos taurus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate
Bos taurus
-
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
-
-
r
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Bos taurus
-
-
-
Purification (Commentary)
Commentary
Organism
liver: 2 isozymes
Bos taurus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
erythrocyte
-
Bos taurus
-
liver
-
Bos taurus
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.0045
-
liver enzyme
Bos taurus
0.136
-
erythrocyte enzyme
Bos taurus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate
-
640349
Bos taurus
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
-
-
-
r
3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate
i.e. 1,3-diphosphoglycerate
640349
Bos taurus
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
-
-
-
r
3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate
specific for 3-phospho-D-glyceroyl phosphate
640349
Bos taurus
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
-
-
-
r
3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate
no acceptor activity mannose 6-phosphate
640349
Bos taurus
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
-
-
-
r
3-phospho-D-glyceroyl phosphate + D-glucose 6-phosphate
-
640349
Bos taurus
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
-
-
-
?
3-phospho-D-glyceroyl phosphate + D-mannose 1-phosphate
-
640349
Bos taurus
3-phospho-D-glycerate + D-mannose 1,6-bisphosphate
-
-
-
?
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
25
-
assay at
Bos taurus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
D-fructose 1,6-diphosphate
strong, liver
Bos taurus
glycerate 2,3-diphosphate
strong, liver
Bos taurus
phosphoenolpyruvate
strong
Bos taurus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.00023
-
3-phospho-D-glyceroyl 1-phosphate
25°C, pH 7.5, liver enzyme peak I
Bos taurus
0.00028
-
3-phospho-D-glyceroyl 1-phosphate
25°C, pH 7.5, liver enzyme peak II
Bos taurus
0.00045
-
3-phospho-D-glyceroyl 1-phosphate
25°C, pH 7.5, erythrocyte enzyme
Bos taurus
0.009
-
D-glucose 1-phosphate
25°C, pH 7.5, liver enzyme peak I
Bos taurus
0.015
-
D-glucose 6-phosphate
25°C, pH 7.5, liver enzyme peak I
Bos taurus
0.059
-
D-glucose 1-phosphate
25°C, pH 7.5, liver enzyme peak II
Bos taurus
0.061
-
D-glucose 6-phosphate
25°C, pH 7.5, liver enzyme peak II
Bos taurus
0.16
-
D-glucose 1-phosphate
25°C, pH 7.5, erythrocyte enzyme
Bos taurus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
soluble
-
Bos taurus
-
-
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Mg2+
-
Bos taurus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate
Bos taurus
-
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
-
-
r
Purification (Commentary) (protein specific)
Commentary
Organism
liver: 2 isozymes
Bos taurus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
erythrocyte
-
Bos taurus
-
liver
-
Bos taurus
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
0.0045
-
liver enzyme
Bos taurus
0.136
-
erythrocyte enzyme
Bos taurus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate
-
640349
Bos taurus
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
-
-
-
r
3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate
i.e. 1,3-diphosphoglycerate
640349
Bos taurus
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
-
-
-
r
3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate
specific for 3-phospho-D-glyceroyl phosphate
640349
Bos taurus
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
-
-
-
r
3-phospho-D-glyceroyl phosphate + D-glucose 1-phosphate
no acceptor activity mannose 6-phosphate
640349
Bos taurus
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
-
-
-
r
3-phospho-D-glyceroyl phosphate + D-glucose 6-phosphate
-
640349
Bos taurus
3-phospho-D-glycerate + D-glucose 1,6-bisphosphate
-
-
-
?
3-phospho-D-glyceroyl phosphate + D-mannose 1-phosphate
-
640349
Bos taurus
3-phospho-D-glycerate + D-mannose 1,6-bisphosphate
-
-
-
?
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
25
-
assay at
Bos taurus
Other publictions for EC 2.7.1.106
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
674867
Maliekal
Molecular identification of ma ...
Homo sapiens
J. Biol. Chem.
282
31844-31851
2007
-
-
1
-
-
-
3
-
-
-
-
-
-
3
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
640349
Ueda
Regulation of glucose 1,6-bisp ...
Bos taurus
J. Biochem.
83
1721-1730
1978
-
-
-
-
-
-
3
8
1
1
-
1
-
1
-
-
1
-
-
2
2
-
6
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
8
1
1
-
1
-
-
-
1
-
2
2
-
6
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
640350
Rose
Inhibitors of glucose-1,6-bisp ...
Bos taurus
J. Biol. Chem.
252
4262-4268
1977
-
-
-
-
-
-
16
3
-
3
-
-
-
1
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
16
-
3
-
3
-
-
-
-
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
640348
Rose
A specific enzyme for glucose ...
Mus musculus
J. Biol. Chem.
250
3466-3470
1975
-
-
-
-
-
-
8
-
1
7
-
1
-
1
-
-
1
-
-
1
-
-
7
-
1
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
8
-
-
1
7
-
1
-
-
-
1
-
1
-
-
7
-
1
-
-
-
1
1
-
-
-
-
-
-
-
-