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Literature summary for 2.7.1.105 extracted from

  • Mehrotra, A.; Trigun, S.K.
    Moderate grade hyperammonemia activates lactate dehydrogenase-4 and 6-phosphofructo-2-kinase to support increased lactate turnover in the brain slices (2013), Mol. Cell. Biochem., 381, 157-161.
    View publication on PubMed
Search for more literature for 2.7.1.105

Application

Application Comment Organism
diagnostics the level of PFK2 is considered as a marker of glycolytic activation at tissue level Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain brain-specific PFK2 isozyme Mus musculus
-

Synonyms

Synonyms Comment Organism
6-phosphofructo-2-kinase
-
 Mus musculus
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
-
 Mus musculus
PFK2/FBPase2
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus the PFK2 expression is increased about 2fold in 0.5 mM ammonia treated brain slices up

General Information

General Information Comment Organism
metabolism moderate grade hyperammonemia activates lactate dehydrogenase-4 and 6-phosphofructo-2-kinase to support increased lactate turnover in the brain slices Mus musculus
physiological function the PFK2 domain of PFK2/FBPase2 regulates glycolysis to maintain the pyruvate pool for lactate synthesis Mus musculus