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Literature summary for 2.7.1.105 extracted from

  • Li, H.; Guo, X.; Xu, H.; Woo, S.; Halim, V.; Morgan, C.; Wu, C.
    A role for inducible 6-phosphofructo-2-kinase in the control of neuronal glycolysis (2013), J. Nutr. Biochem., 24, 1153-1158.
    View publication on PubMed
Search for more literature for 2.7.1.105

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + beta-D-fructose 6-phosphate Mus musculus
-
 ADP + beta-D-fructose 2,6-bisphosphate
-
 ?
ATP + beta-D-fructose 6-phosphate Mus musculus C57/BL6J
-
 ADP + beta-D-fructose 2,6-bisphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus A7UAK5 gene PFKFB3, isozyme iPFK2 is inducible
-
Mus musculus C57/BL6J A7UAK5 gene PFKFB3, isozyme iPFK2 is inducible
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
hypothalamus
-
 Mus musculus
-
N-43/5 cell
-
 Mus musculus
-
neuron isozyme iPFK2 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + beta-D-fructose 6-phosphate
-
 Mus musculus ADP + beta-D-fructose 2,6-bisphosphate
-
 ?
ATP + beta-D-fructose 6-phosphate
-
 Mus musculus C57/BL6J ADP + beta-D-fructose 2,6-bisphosphate
-
 ?

Synonyms

Synonyms Comment Organism
6-phosphofructo-2-kinase
-
 Mus musculus
iPFK2
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus re-feeding increases plasma levels of glucose and insulin and stimulates PFKFB3 expression. Glucose and insulin stimulate PFKFB3 expression, increase glycolysis, and decrease AMPK phosphorylation in clonal hypothalamic neurons up

General Information

General Information Comment Organism
malfunction knockdown of PFKFB3/iPFK2 in N-43/5 neurons causes a decrease in rates of glycolysis, which is accompanied by increased AMPK phosphorylation, increased AgRP mRNA levels and decreased CART mRNA levels. Overexpression of PFKFB3/iPFK2 in N-43/5 neurons causes an increase in glycolysis, which is accompanied by decreased AMPK phosphorylation and decreased AgRP mRNA levels and increased CART mRNA levels Mus musculus
metabolism re-feeding increases plasma levels of glucose and insulin and stimulates PFKFB3 expression. Glucose and insulin stimulate PFKFB3 expression, increase glycolysis, and decrease AMPK phosphorylation in clonal hypothalamic neurons Mus musculus
physiological function role for PFKFB3/iPFK2 in regulating glycolysis in hypothalamic neurons, in the context of neuronal glucose sensing and neuropeptide expression. PFKFB3/iPFK2 responds to re-feeding, which in turn stimulates hypothalamic glycolysis and decreases hypothalamic AMPK phosphorylation and alters neuropeptide expression in a pattern that is associated with suppression of food intake Mus musculus