Cloned (Comment) | Organism |
---|---|
gene PFKFB3 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + beta-D-fructose 6-phosphate | Homo sapiens | - |
ADP + beta-D-fructose 2,6-bisphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q16875 | gene PFKFB3 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colon adenocarcinoma cell | - |
Homo sapiens | - |
HCT-116 cell | - |
Homo sapiens | - |
additional information | enzyme PFKFB3 is highly expressed and activated in human cancer cells | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + beta-D-fructose 6-phosphate | - |
Homo sapiens | ADP + beta-D-fructose 2,6-bisphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
6-phosphofructo-2-kinase | - |
Homo sapiens |
PFKFB3 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | enzyme PFKFB3 belongs to the family of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFKFBs) that controls the conversion of fructose-6-phosphate to and from fructose-2,6-bisphosphate, a key regulator of the glycolytic enzyme phosphofructokinase-1 | Homo sapiens |