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Literature summary for 2.7.1.105 extracted from

  • Klarer, A.C.; ONeal, J.; Imbert-Fernandez, Y.; Clem, A.; Ellis, S.R.; Clark, J.; Clem, B.; Chesney, J.; Telang, S.
    Inhibition of 6-phosphofructo-2-kinase (PFKFB3) induces autophagy as a survival mechanism (2014), Cancer Metab., 2, 2.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene PFKFB3 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + beta-D-fructose 6-phosphate Homo sapiens
-
ADP + beta-D-fructose 2,6-bisphosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q16875 gene PFKFB3
-

Source Tissue

Source Tissue Comment Organism Textmining
colon adenocarcinoma cell
-
Homo sapiens
-
HCT-116 cell
-
Homo sapiens
-
additional information enzyme PFKFB3 is highly expressed and activated in human cancer cells Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + beta-D-fructose 6-phosphate
-
Homo sapiens ADP + beta-D-fructose 2,6-bisphosphate
-
?

Synonyms

Synonyms Comment Organism
6-phosphofructo-2-kinase
-
Homo sapiens
PFKFB3
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens

General Information

General Information Comment Organism
physiological function enzyme PFKFB3 belongs to the family of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFKFBs) that controls the conversion of fructose-6-phosphate to and from fructose-2,6-bisphosphate, a key regulator of the glycolytic enzyme phosphofructokinase-1 Homo sapiens