Literature summary for 2.7.1.105 extracted from

Gomez, M.; Navarro-Sabate, A.; Manzano, A.; Duran, J.; Obach, M.; Bartrons, R.
Switches in 6-phosphofructo-2-kinase isoenzyme expression during rat sperm maturation (2009), Biochem. Biophys. Res. Commun., 387, 330-335.

Search for more literature for 2.7.1.105

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
acrosome	tPFK-2	Rattus norvegicus	-	-
flagellum	tPFK-2	Rattus norvegicus	-	-

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	Sprague-Dawley rat	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
interstitial cell	uPFK-2	Rattus norvegicus	-
Sertoli cell	uPFK-2	Rattus norvegicus	-
sperm flagellum	-	Rattus norvegicus	-
spermatocyte	uPFK-2, tPFK-2	Rattus norvegicus	-
testis	-	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
6-phosphofructo-2-kinase	-	Rattus norvegicus
PFKFB3	-	Rattus norvegicus
PFKFB3	gene name of isoform	Rattus norvegicus
PFKFB4	-	Rattus norvegicus
PFKFB4	gene name of isoform	Rattus norvegicus
tPFK-2	isoform, product of Pfkfb4 gene	Rattus norvegicus
uPFK-2	isoform, product of Pfkfb3 gene	Rattus norvegicus

Expression

Organism	Comment	Expression
Rattus norvegicus	maximum expression of Pfkfb3 in cells before puberty, maximum expression of Pfkfb4 in adult cells	up

General Information

General Information	Comment	Organism
metabolism	glycolytic enzyme is present as testis-specific isoforms, these isoforms are expressed specifically or predominantly in spermatogenic cells, often during the post-meiotic phase, and replace the ubiquitous isozymes that are also present in somatic cells	Rattus norvegicus
physiological function	spermatogenesis, both PFK-2 isozymes have specific roles in testis metabolism and physiology, PFK-2 isozyme expression switches from the ubiquitous form, required during proliferative phases, to the testicular form, which is the germ cell-specific one	Rattus norvegicus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)