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Literature summary for 2.7.1.105 extracted from
- 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase and tumor cell glycolysis (2006), Curr. Opin. Clin. Nutr. Metab. Care, 9, 535-539.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | the key role of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in neoplastic transformation provides a rational for the development of agents that selectively inhibit the PFKFB3 enzyme as antineoplastic agents | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | PFKFB3 is activated by mitogenic inflammatory and hypoxic stimuli. PFKFB4 controls glycolytic flux to lactate and the nonoxidatibe pentose shunt, and is selectively required for the tumorigenic growth of ras-transformed cells | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| leukemia cell | PFKFB3 is constitutively expressed | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | PFKFB3 is activated by mitogenic inflammatory and hypoxic stimuli. PFKFB4 controls glycolytic flux to lactate and the nonoxidatibe pentose shunt, and is selectively required for the tumorigenic growth of ras-transformed cells | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase | - |
Homo sapiens |
| PFKFB3 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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