Literature summary for 2.7.1.105 extracted from

Rider, M.H.; Vandamme, J.; Lebeau, E.; Vertommen, D.; Vidal, H.; Rousseau, G.G.; Vanderkerkhove, J.; Hue, L.
The two forms of bovine heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase result from alternative splicing (1992), Biochem. J., 285, 405-411.

No PubMed abstract available

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Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
55000	-	2 * 55000, SDS-PAGE	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-
Rattus norvegicus	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	phosphorylation site	Bos taurus
phosphoprotein	phophorylation by cAMP-dependent protein kinase causes activation	Rattus norvegicus
phosphoprotein	phophorylation by cAMP-dependent protein kinase causes activation	Bos taurus

Purification (Commentary)

Purification (Comment)	Organism
2 enzyme forms	Bos taurus
heart	Bos taurus

Reaction

Reaction	Comment	Organism	Reaction ID
ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate	bifunctional protein: 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, reverse reaction catalysed by fructose 2,6-bisphosphatase: 3.1.3.46	Rattus norvegicus	a
ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate	bifunctional protein: 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, reverse reaction catalysed by fructose 2,6-bisphosphatase: 3.1.3.46	Bos taurus	a

Source Tissue

Source Tissue	Comment	Organism	Textmining
heart	-	Rattus norvegicus	-
heart	2 isozymes: result of alternative splitting of the same primary transcript	Bos taurus	-
liver	-	Rattus norvegicus	-
liver	-	Bos taurus	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.04	-	-	Bos taurus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + beta-D-fructose 6-phosphate	-	Rattus norvegicus	ADP + beta-D-fructose 2,6-bisphosphate	-	r
ATP + beta-D-fructose 6-phosphate	-	Bos taurus	ADP + beta-D-fructose 2,6-bisphosphate	-	r
additional information	also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46)	Rattus norvegicus	?	-	?
additional information	also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46)	Bos taurus	?	-	?

Subunits

Subunits	Comment	Organism
dimer	-	Bos taurus
dimer	2 * 55000, SDS-PAGE	Rattus norvegicus
More	-	Rattus norvegicus
More	two isozymes: 58000 Da and 54000 Da, SDS-Page	Bos taurus

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Release 2023.1 (January 2023)