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Literature summary for 2.7.1.105 extracted from
- Phosphate dependency of phosphofructokinase 2 (1985), Eur. J. Biochem., 148, 155-159.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| beta-D-fructose 2,6-bisphosphate | - |
Rattus norvegicus |  |
| citrate | - |
Rattus norvegicus | |
| citrate | - |
Saccharomyces cerevisiae | |
| citrate | - |
Spinacia oleracea | |
| additional information | phosphorylation at lower pH-values; phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme | Rattus norvegicus | |
| additional information | - |
Spinacia oleracea | |
| phosphoenolpyruvate | - |
Rattus norvegicus | |
| phosphoenolpyruvate | - |
Saccharomyces cerevisiae | |
| phosphoenolpyruvate | - |
Spinacia oleracea | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| AsO43- | requirement | Rattus norvegicus | |
| AsO43- | can replace phosphate | Rattus norvegicus | |
| Mg2+ | - |
Rattus norvegicus | |
| Mg2+ | - |
Saccharomyces cerevisiae | |
| Mg2+ | - |
Spinacia oleracea | |
| phosphate | requirement | Rattus norvegicus | |
| phosphate | requirement | Saccharomyces cerevisiae | |
| phosphate | requirement | Spinacia oleracea | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
| Spinacia oleracea | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | - |
Saccharomyces cerevisiae |
| phosphoprotein | - |
Spinacia oleracea |
| phosphoprotein | phosphorylation at lower pH-values | Rattus norvegicus |
| phosphoprotein | phosphorylation by cAMP-dependent protein kinase causes inactivation of liver enzyme | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| leaf | - |
Spinacia oleracea | - |
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + beta-D-fructose 6-phosphate | - |
Rattus norvegicus | ADP + beta-D-fructose 2,6-bisphosphate | - |
? | |
| ATP + beta-D-fructose 6-phosphate | - |
Saccharomyces cerevisiae | ADP + beta-D-fructose 2,6-bisphosphate | - |
? | |
| ATP + beta-D-fructose 6-phosphate | - |
Spinacia oleracea | ADP + beta-D-fructose 2,6-bisphosphate | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Rattus norvegicus |
| 30 | - |
assay at | Saccharomyces cerevisiae |
| 30 | - |
assay at | Spinacia oleracea |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 57 | - |
10 min, pH 7.1, progressive inactivation, phosphate does not protect | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| AMP | activation, 0.025 mM | Rattus norvegicus | |
| AMP | activation, 0.025 mM | Saccharomyces cerevisiae | |
| AMP | activation, 0.025 mM | Spinacia oleracea | |
| GMP | activation | Rattus norvegicus | |
| IMP | activation | Rattus norvegicus | |
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