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Literature summary for 2.7.1.103 extracted from

  • Skinner, R.H.; Cundliffe, E.
    Resistance to the antibiotics viomycin and capreomycin in the Streptomyces species which produce them (1980), J. Gen. Microbiol., 120, 95-104.
    View publication on PubMed

Application

Application Comment Organism
medicine antibiotic-inactivating enzyme Saccharothrix mutabilis subsp. capreolus
medicine antibiotic-inactivating enzyme Streptomyces vinaceus

Cloned(Commentary)

Cloned (Comment) Organism
shotgun cloning, resistance to viomycin is cloned into Streptomyces lividans, recombinant clones are cross resistant to capreomycin IA, but not to capreomycin IB Streptomyces vinaceus

Localization

Localization Comment Organism GeneOntology No. Textmining
ribosome postribosomal supernatant (S100-fraction), intracellular or cytoplasmic membrane associated Saccharothrix mutabilis subsp. capreolus 5840
-
ribosome postribosomal supernatant (S100-fraction), intracellular or cytoplasmic membrane associated Streptomyces vinaceus 5840
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + viomycin Saccharothrix mutabilis subsp. capreolus antibiotic-inactivating enzymes, involved in self-defence mechanism ADP + O-phosphoviomycin
-
?
ATP + viomycin Streptomyces vinaceus antibiotic-inactivating enzymes, involved in self-defence mechanism ADP + O-phosphoviomycin
-
?

Organism

Organism UniProt Comment Textmining
no activity in Streptomyces coelicolor
-
standard reference actinomycete, sensitive to viomycin and capreomycin
-
no activity in Streptomyces coelicolor A
-
standard reference actinomycete, sensitive to viomycin and capreomycin
-
Saccharothrix mutabilis subsp. capreolus
-
NCIB 9801
-
Streptomyces vinaceus
-
NCIB 8852
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + capreomycin IA capreomycin I B poor substrate Saccharothrix mutabilis subsp. capreolus ADP + O-phosphocapreomycin IA
-
?
ATP + capreomycin IA capreomycin I B poor substrate Streptomyces vinaceus ADP + O-phosphocapreomycin IA
-
?
ATP + capreomycin IIA
-
Saccharothrix mutabilis subsp. capreolus ADP + O-phosphocapreomycin IIA
-
?
ATP + capreomycin IIA
-
Streptomyces vinaceus ADP + O-phosphocapreomycin IIA
-
?
ATP + viomycin
-
Saccharothrix mutabilis subsp. capreolus ADP + O-phosphoviomycin
-
?
ATP + viomycin
-
Streptomyces vinaceus ADP + O-phosphoviomycin
-
?
ATP + viomycin antibiotic-inactivating enzymes, involved in self-defence mechanism Saccharothrix mutabilis subsp. capreolus ADP + O-phosphoviomycin
-
?
ATP + viomycin antibiotic-inactivating enzymes, involved in self-defence mechanism Streptomyces vinaceus ADP + O-phosphoviomycin
-
?
additional information a serine residue acts as phosphate-acceptor Saccharothrix mutabilis subsp. capreolus ?
-
?
additional information a serine residue acts as phosphate-acceptor Streptomyces vinaceus ?
-
?
additional information capreomycin IIB is no substrate Streptomyces vinaceus ?
-
?