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Literature summary for 2.7.1.1 extracted from

  • Kochel, K.; Tomczyk, M.; Simoes, R.; Fraczek, T.; Sobon, A.; Oliveira, P.; Walczak, K.; Koceva-Chyla, A.
    Evaluation of biological properties of 3,3',4,4'-benzophenonetetracarboxylic dianhydride derivatives and their ability to inhibit hexokinase activity (2017), Bioorg. Med. Chem. Lett., 27, 427-431 .
    View publication on PubMed
Search for more literature for 2.7.1.1

Inhibitors

Inhibitors Comment Organism Structure
N,N'-bis(3-hydroxyphenyl)benzophenone-3,3',4,4'-tetracarboxylic diimide decrease hexokinase activity in a dose-dependent manner Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.42
-
 D-glucose pH and temperature not specified in the publication Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus O08528
-
-

Source Tissue

Source Tissue Comment Organism Textmining
P-19 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + D-glucose
-
 Mus musculus ADP + D-glucose 6-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
hexokinase II
-
 Mus musculus
HKII
-
 Mus musculus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
93.39
-
 D-glucose pH and temperature not specified in the publication Mus musculus

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
222.4
-
 D-glucose pH and temperature not specified in the publication Mus musculus