Literature summary for 2.7.1.1 extracted from

Fraga, A.; Moraes, J.; da Silva, J.R.; Costa, E.P.; Menezes, J.; da Silva Vaz, I.; Logullo, C.; da Fonseca, R.N.; Campos, E.
Inorganic polyphosphates regulate hexokinase activity and reactive oxygen species generation in mitochondria of Rhipicephalus (Boophilus) microplus embryo (2013), Int. J. Biol. Sci., 9, 842-852.

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Inhibitors

Inhibitors	Comment	Organism	Structure
polyphosphate P3	up to 90% inhibition	Rhipicephalus microplus
polyphosphate P5	up to 90% inhibition	Rhipicephalus microplus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	the mitochondrial membrane exopolyphosphatase activity is stimulated by the hexokinase reaction product, glucose-6-phosphate. Polyphosphates increase hydrogen peroxide generation in mitochondria in a situation where mitochondrial hexokinase is also active	Rhipicephalus microplus	5739	-

Organism

Organism	UniProt	Comment	Textmining
Rhipicephalus microplus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
embryo	the superoxide dismutase, catalase and glutathione reductase activities are higher during embryo cellularization, at the end of embryogenesis and during embryo segmentation, respectively. All of the enzymes are stimulated by polyphosphate P3, which is inhibitory to hexokinase	Rhipicephalus microplus	-

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Release 2023.1 (January 2023)