Inhibitors | Comment | Organism | Structure |
---|---|---|---|
KCl | - |
Littorina littorea | |
NaCl | - |
Littorina littorea | |
NH4Cl | - |
Littorina littorea | |
Urea | - |
Littorina littorea |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.059 | - |
D-glucose | enzyme from hepatopancreas, 24 h anoxic conditions, pH 7.5, 22°C | Littorina littorea | |
0.091 | - |
D-glucose | enzyme from hepatopancreas, pH 7.5, 22°C | Littorina littorea | |
0.14 | - |
ATP | enzyme from hepatopancreas, 24 h anoxic conditions, pH 7.5, 22°C | Littorina littorea | |
0.15 | - |
D-glucose | enzyme from foot muscle, 24 h anoxic conditions, pH 7.5, 22°C | Littorina littorea | |
0.15 | - |
D-glucose | enzyme from foot muscle, pH 7.5, 22°C | Littorina littorea | |
0.16 | - |
ATP | enzyme from hepatopancreas, pH 7.5, 22°C | Littorina littorea | |
0.24 | - |
ATP | enzyme from foot muscle, pH 7.5, 22°C | Littorina littorea | |
0.55 | - |
ATP | enzyme from foot muscle, 24 h anoxic conditions, pH 7.5, 22°C | Littorina littorea |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Littorina littorea | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
foot muscle | during anoxia, an increase in Km for ATP and a decrease in Vmax for anoxic snail hexokinase are consistent with a less active enzyme | Littorina littorea | - |
hepatopancreas | during anoxia, a reduction in the Km for glucose for hexokinase from the anoxic animal suggests a more active enzyme form | Littorina littorea | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + D-glucose | - |
Littorina littorea | ADP + D-glucose 6-phosphate | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
190 | - |
enzyme from foot muscle, 24 h anoxic conditions, pH 7.5, 22°C | Littorina littorea | NH4Cl | |
210 | - |
enzyme from foot muscle, pH 7.5, 22°C | Littorina littorea | NH4Cl | |
230 | - |
enzyme from hepatopancreas, 24 h anoxic conditions, pH 7.5, 22°C | Littorina littorea | NH4Cl | |
230 | - |
enzyme from hepatopancreas, pH 7.5, 22°C | Littorina littorea | NH4Cl | |
240 | - |
enzyme from hepatopancreas, pH 7.5, 22°C | Littorina littorea | NaCl | |
260 | - |
enzyme from hepatopancreas, 24 h anoxic conditions, pH 7.5, 22°C | Littorina littorea | KCl | |
260 | - |
enzyme from hepatopancreas, pH 7.5, 22°C | Littorina littorea | KCl | |
280 | - |
enzyme from foot muscle, 24 h anoxic conditions, pH 7.5, 22°C | Littorina littorea | KCl | |
280 | - |
enzyme from foot muscle, pH 7.5, 22°C | Littorina littorea | NaCl | |
280 | - |
enzyme from foot muscle, pH 7.5, 22°C | Littorina littorea | KCl | |
290 | - |
enzyme from hepatopancreas, 24 h anoxic conditions, pH 7.5, 22°C | Littorina littorea | NaCl | |
300 | - |
enzyme from foot muscle, 24 h anoxic conditions, pH 7.5, 22°C | Littorina littorea | NaCl | |
990 | - |
enzyme from foot muscle, 24 h anoxic conditions, pH 7.5, 22°C | Littorina littorea | Urea | |
1170 | - |
enzyme from foot muscle, pH 7.5, 22°C | Littorina littorea | Urea | |
1310 | - |
enzyme from hepatopancreas, 24 h anoxic conditions, pH 7.5, 22°C | Littorina littorea | Urea | |
1490 | - |
enzyme from hepatopancreas, pH 7.5, 22°C | Littorina littorea | Urea |
General Information | Comment | Organism |
---|---|---|
physiological function | dephosphorylation and activation of hepatopancreas hexokinase during anoxia may allow for increased shunting of glucose-6-phosphate into the pentose phosphate pathway, thereby producing reducing equivalents of NADPH. The activation of endogenous protein kinase C and AMP-activated protein kinase increase the Km for glucose for anoxic hepatopancreas hexokinase to a value that is similar to the control Km for glucose. Stimulation of endogenous protein kinase C, protein kinase G, and Calcium/calmodulin activated protein kinase for foot muscle hexokinase increase the Km for ATP to a value similar to that seen for the anoxic enzyme form. In both tissues, activation of endogenous phosphatases reverses the effects of protein kinases | Littorina littorea |