Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cerebral cortex | - |
Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
hexokinase II | - |
Rattus norvegicus |
HKII | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | hypoxia-inducible factor (HIF)-1-regulated glycolytic enzyme hexokinase II (HKII) acts as a molecular switch that determines cellular fate by regulating both cytoprotection and induction of apoptosis based on the metabolic state. Together with phosphoprotein enriched in astrocytes (PEA15), HKII inhibits apoptosis after hypoxia. In contrast, HKII accelerates apoptosis in the absence of PEA15 and under glucose deprivation | Rattus norvegicus |