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Literature summary for 2.7.1.1 extracted from
- A hepatic protein modulates glucokinase activity in fish and avian liver: a comparative study (2009), J. Comp. Physiol. B, 179, 643-652.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| glucokinase regulatory protein | inhibits competitively GCK activity with D-glucose, inhibition of glucokinase activity by glucokinase regulatory protein in vivo is enhanced by fructose 6-phosphate or sorbitol 6-phosphate | Carassius auratus | |
| glucokinase regulatory protein | inhibits competitively GCK activity with D-glucose, inhibition of glucokinase activity by glucokinase regulatory protein in vivo is enhanced by fructose 6-phosphate or sorbitol 6-phosphate | Cyprinus carpio | |
| glucokinase regulatory protein | inhibits competitively GCK activity with D-glucose, inhibition of glucokinase activity by glucokinase regulatory protein in vivo is enhanced by fructose 6-phosphate or sorbitol 6-phosphate | Gallus gallus | |
| glucokinase regulatory protein | inhibits competitively GCK activity with D-glucose, inhibition of glucokinase activity by glucokinase regulatory protein in vivo is enhanced by fructose 6-phosphate or sorbitol 6-phosphate | Oncorhynchus mykiss | |
| glucokinase regulatory protein | inhibits competitively GCK activity with D-glucose, inhibition of glucokinase activity by glucokinase regulatory protein in vivo is enhanced by fructose 6-phosphate or sorbitol 6-phosphate | Rattus norvegicus | |
| additional information | not inhibited by D-glucose 6-phosphate | Carassius auratus | |
| additional information | not inhibited by D-glucose 6-phosphate | Cyprinus carpio | |
| additional information | not inhibited by D-glucose 6-phosphate | Gallus gallus | |
| additional information | not inhibited by D-glucose 6-phosphate | Oncorhynchus mykiss | |
| additional information | not inhibited by D-glucose 6-phosphate | Rattus norvegicus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| K+ | increases the activity of glucokinase | Gallus gallus |  |
| K+ | increases the activity of glucokinase | Rattus norvegicus | |
| K+ | increases the activity of glucokinase | Carassius auratus | |
| K+ | increases the activity of glucokinase | Cyprinus carpio | |
| K+ | increases the activity of glucokinase | Oncorhynchus mykiss | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Carassius auratus | - |
- |
- |
| Cyprinus carpio | - |
- |
- |
| Gallus gallus | - |
- |
- |
| Oncorhynchus mykiss | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Gallus gallus | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Carassius auratus | - |
| liver | - |
Cyprinus carpio | - |
| liver | - |
Oncorhynchus mykiss | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + D-glucose | - |
Gallus gallus | ADP + D-glucose 6-phosphate | - |
? | |
| ATP + D-glucose | - |
Rattus norvegicus | ADP + D-glucose 6-phosphate | - |
? | |
| ATP + D-glucose | - |
Carassius auratus | ADP + D-glucose 6-phosphate | - |
? | |
| ATP + D-glucose | - |
Cyprinus carpio | ADP + D-glucose 6-phosphate | - |
? | |
| ATP + D-glucose | - |
Oncorhynchus mykiss | ADP + D-glucose 6-phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GCK | - |
Gallus gallus |
| GCK | - |
Rattus norvegicus |
| GCK | - |
Carassius auratus |
| GCK | - |
Cyprinus carpio |
| GCK | - |
Oncorhynchus mykiss |
| glucokinase | - |
Gallus gallus |
| glucokinase | - |
Rattus norvegicus |
| glucokinase | - |
Carassius auratus |
| glucokinase | - |
Cyprinus carpio |
| glucokinase | - |
Oncorhynchus mykiss |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Gallus gallus | |
| ATP | - |
Rattus norvegicus | |
| ATP | - |
Carassius auratus | |
| ATP | - |
Cyprinus carpio | |
| ATP | - |
Oncorhynchus mykiss | |
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