BRENDA - Enzyme Database
show all sequences of 2.7.1.1

Apoptosis-inducing antitumor efficacy of hexokinase II inhibitor in hepatocellular carcinoma

Kim, W.; Yoon, J.H.; Jeong, J.M.; Cheon, G.J.; Lee, T.S.; Yang, J.I.; Park, S.C.; Lee, H.S.; Mol. Cancer Ther. 6, 2554-2562 (2007)

Data extracted from this reference:

Application
Application
Commentary
Organism
medicine
HK II inhibitors may be therapeutically useful for the treatment of advanced infiltrative hypovascular hepatocellular carcinomas, which are growing in a hypoxic environment
Mus musculus
Inhibitors
Inhibitors
Commentary
Organism
Structure
3-Bromopyruvate
in mice treated with 3-bromopyruvate, mean tumor volumes and tumor volume growth are significantly reduced
Mus musculus
Organism
Organism
UniProt
Commentary
Textmining
Mus musculus
-
C3H mice implanted with MH134 cells
-
Synonyms
Synonyms
Commentary
Organism
hexokinase II
-
Mus musculus
HK II
-
Mus musculus
Application (protein specific)
Application
Commentary
Organism
medicine
HK II inhibitors may be therapeutically useful for the treatment of advanced infiltrative hypovascular hepatocellular carcinomas, which are growing in a hypoxic environment
Mus musculus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
3-Bromopyruvate
in mice treated with 3-bromopyruvate, mean tumor volumes and tumor volume growth are significantly reduced
Mus musculus
Other publictions for EC 2.7.1.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)