Literature summary for 2.7.1.1 extracted from

Chambers, J.W.; Fowler, M.L.; Morris, M.T.; Morris, J.C.
The anti-trypanosomal agent lonidamine inhibits Trypanosoma brucei hexokinase 1 (2008), Mol. Biochem. Parasitol., 158, 202-207.

Search for more literature for 2.7.1.1

Application

Application	Comment	Organism
medicine	TbHK1 is a valid therapeutic target while identifying a potential molecular target of the anti-trypanosomal agent lonidamine	Trypanosoma brucei

Inhibitors

Inhibitors	Comment	Organism	Structure
lonidamine	lonidamine is toxic to cultured bloodstream form parasites and procyclic form parasites. Overexpression of TbHK1 protects procyclic forms from lonidamine	Trypanosoma brucei

Organism

Organism	UniProt	Comment	Textmining
Trypanosoma brucei	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
bloodstream form	TbHK1 is essential to the bloodstream form. Silencing the gene for 4 days reduces cellular hexokinase about 60% and leads to parasite death	Trypanosoma brucei	-

Synonyms

Synonyms	Comment	Organism
hexokinase 1	-	Trypanosoma brucei
TbHK1	-	Trypanosoma brucei

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.85	-	recombinant enzyme	Trypanosoma brucei	lonidamine

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Release 2023.1 (January 2023)