Literature summary for 2.7.1.1 extracted from

Romero-Navarro, G.; Lopez-Aceves, T.; Rojas-Ochoa, A.; Fernandez Mejia, C.
Effect of dichlorvos on hepatic and pancreatic glucokinase activity and gene expression, and on insulin mRNA levels (2006), Life Sci., 78, 1015-1020.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Rattus norvegicus	the enzyme plays a role in glycogen synthesis and glucose homeostasis	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	three days of dichlorvos administration (20 ng/kg body weight) results in increase of glucokinase mRNA levels and decrease in enzyme activity	Rattus norvegicus	-
pancreas	three days of dichlorvos administration (20 ng/kg body weight) has no affect on pancreatic glucokinase activity as well as mRNA levels	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the enzyme plays a role in glycogen synthesis and glucose homeostasis	Rattus norvegicus	?	-	?

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Release 2023.1 (January 2023)