Literature summary for 2.7.1.1 extracted from

Baltrusch, S.; Francini, F.; Lenzen, S.; Tiedge, M.
Interaction of glucokinase with the liver regulatory protein is conferred by leucine-asparagine motifs of the enzyme (2005), Diabetes, 54, 2829-2837.

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Protein Variants

Protein Variants	Comment	Organism
L309R/N313Y	significantly reduced interaction with glucokinase regulatory protein	Rattus norvegicus
L355R/N350Y	mutant has a fivefold-higher binding affinity for glucokinase regulatory protein than wild-type glucokinase	Rattus norvegicus
L58R	7fold reduced interaction with glucokinase regulatory protein	Rattus norvegicus
L58R/N204Y	10fold reduced interaction with glucokinase regulatory protein. Mutant lacks glucose-dependent translocation by glucokinase regulatory protein	Rattus norvegicus
N204Y	12fold reduced interaction with glucokinase regulatory protein	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-

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Release 2023.1 (January 2023)