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Literature summary for 2.7.1.1 extracted from

  • Röber, B.; Stolle, J.; Reuter, G.
    Eigenschaften der Hexokinase aus der SCP Hefe Candida maltosa H (1984), Z. Allg. Mikrobiol., 24, 619-627.
No PubMed abstract available

Activating Compound

Activating Compound Comment Organism Structure
galactose activates isoenzyme Hex II Candida maltosa
isocitrate activates isoenzyme Hex II Candida maltosa
lyxose activates isoenzyme Hex II Candida maltosa
mannose 6-phosphate activates isoenzyme Hex II Candida maltosa
phosphoenolpyruvate activates isoenzyme Hex I Candida maltosa
ribose activates isoenzyme Hex II Candida maltosa
xylose activates isoenzyme Hex II Candida maltosa

Inhibitors

Inhibitors Comment Organism Structure
ADP
-
Candida maltosa
D-mannose
-
Candida maltosa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information
-
Candida maltosa

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Candida maltosa
Mg2+ below 3 mM Candida maltosa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
96000
-
Hex II, gel filtration Candida maltosa
110000
-
gel filtration Candida maltosa
110000
-
Hex I Candida maltosa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glucose + ATP Candida maltosa isoenzymes are a target for effective control of glucose 6-phosphate formation by energy charge of the cell or by the intracellular level of ATP, ADP and glucose instead of allosteric interconversions of the enzyme D-glucose 6-phosphate + ADP
-
?

Organism

Organism UniProt Comment Textmining
Candida maltosa
-
H, isoenzymes Hex I and Hex II
-

Purification (Commentary)

Purification (Comment) Organism
isoenzymes Hex I and Hex II, partial Candida maltosa

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Candida maltosa
0.11 0.16 Hex I and II, at pH 8.2 Candida maltosa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucose + ATP specific for ATP Candida maltosa ADP + D-glucose 6-phosphate
-
?
D-glucose + ATP isoenzymes are a target for effective control of glucose 6-phosphate formation by energy charge of the cell or by the intracellular level of ATP, ADP and glucose instead of allosteric interconversions of the enzyme Candida maltosa D-glucose 6-phosphate + ADP
-
?
D-mannose + ATP
-
Candida maltosa ADP + D-mannose 6-phosphate
-
?
additional information not: UTP Candida maltosa ?
-
?
additional information not: ITP Candida maltosa ?
-
?
additional information not: GTP Candida maltosa ?
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5 8.5 isoenzyme Hex II Candida maltosa
7.5 8.2 isoenzyme Hex I Candida maltosa
8.2
-
assay at Candida maltosa

Cofactor

Cofactor Comment Organism Structure
ATP
-
Candida maltosa