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Literature summary for 2.7.1.1 extracted from

  • Vandercammen, A.; Van Schaftingen, E.
    Competitive inhibition of liver glucokinase by its regulatory protein (1991), Eur. J. Biochem., 200, 545-551.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
acetate noncompetitive to glucose Rattus norvegicus
Br- noncompetitive to glucose Rattus norvegicus
Cl- noncompetitive to glucose Rattus norvegicus
F- noncompetitive to glucose Rattus norvegicus
I- noncompetitive to glucose Rattus norvegicus
additional information enzymes from rat brain and bovine heart are not inhibited by palmitoyl-CoA or regulatory protein Bos taurus
additional information enzymes from rat brain and bovine heart are not inhibited by palmitoyl-CoA or regulatory protein Rattus norvegicus
additional information
-
Sus scrofa
N-acetyl-D-glucosamine
-
Rattus norvegicus
NO3- noncompetitive to glucose Rattus norvegicus
palmitoyl-CoA inhibition of enzymes from rat liver, pig liver, Buffo marinus, no inhibition: rat brain, bovine heart, yeast; inhibitor binds to a site distinct from the catalytic site, noncompetitive to MgATP2-, competitive to glucose, synergistic with N-acetylglucosamine Rattus norvegicus
palmitoyl-CoA inhibition of enzymes from rat liver, pig liver, Buffo marinus, no inhibition: rat brain, bovine heart, yeast Rhinella marina
palmitoyl-CoA inhibition of enzymes from rat liver, pig liver, Buffo marinus, no inhibition: rat brain, bovine heart, yeast Sus scrofa
phosphate noncompetitive to glucose Rattus norvegicus
phosphate
-
Sus scrofa
Regulatory protein inhibition of enzymes from rat liver, pig liver, Buffo marinus, no inhibition: rat brain, bovine heart, yeast; inhibitor binds to a site distinct from the catalytic site, noncompetitive to MgATP2-, competitive to glucose, synergistic with N-acetylglucosamine, phosphate and sulfate decrease inhibition, monovalent anions antagonize inhibition with the following decreasing order of potency: I-, Br-, NO3-, Cl-, F-, acetate Rattus norvegicus
Regulatory protein inhibition of enzymes from rat liver, pig liver, Buffo marinus, no inhibition: rat brain, bovine heart, yeast Rhinella marina
Regulatory protein inhibition of enzymes from rat liver, pig liver, Buffo marinus, no inhibition: rat brain, bovine heart, yeast Sus scrofa
SO42- noncompetitive to glucose Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.1
-
2-deoxy-D-glucose rat brain enzyme, hexokinase I Rattus norvegicus
0.125
-
2-deoxy-D-glucose
-
Bos taurus
0.125
-
2-deoxy-D-glucose bovine heart enzyme, hexokinase II Rattus norvegicus
5.5
-
D-glucose hexokinase IV Sus scrofa
9
-
2-deoxy-D-glucose rat liver enzyme, hexokinase IV Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
hexokinase II
-
Rattus norvegicus
-
hexokinase IV or D
-
Rhinella marina
-
-
-
Sus scrofa
-
hexokinase IV
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus
-
Sus scrofa
-
Rhinella marina

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Bos taurus
-
liver
-
Sus scrofa
-
liver hexokinase IV or D Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 2-deoxy-D-glucose
-
Rattus norvegicus ADP + 2-deoxy-D-glucose 6-phosphate
-
?
ATP + 2-deoxy-D-glucose
-
Sus scrofa ADP + 2-deoxy-D-glucose 6-phosphate
-
?
ATP + 2-deoxy-D-glucose
-
Bos taurus ADP + 2-deoxy-D-glucose 6-phosphate
-
?
D-glucose + ATP
-
Rattus norvegicus ADP + D-glucose 6-phosphate
-
?
D-glucose + ATP
-
Sus scrofa ADP + D-glucose 6-phosphate
-
?
D-glucose + ATP
-
Bos taurus ADP + D-glucose 6-phosphate
-
?
D-glucose + ATP
-
Rhinella marina ADP + D-glucose 6-phosphate
-
?
D-mannose + ATP
-
Rattus norvegicus ADP + D-mannose 6-phosphate
-
?
D-mannose + ATP
-
Sus scrofa ADP + D-mannose 6-phosphate
-
?
additional information
-
Sus scrofa ?
-
?
additional information not: D-galactose Rattus norvegicus ?
-
?
additional information not: trehalose Rattus norvegicus ?
-
?

Cofactor

Cofactor Comment Organism Structure
ATP
-
Rattus norvegicus
ATP
-
Sus scrofa
ATP
-
Bos taurus
ATP
-
Rhinella marina

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0035
-
palmitoyl-CoA
-
Rattus norvegicus
1.6
-
palmitoyl-CoA
-
Sus scrofa