Literature summary for 2.6.1.B19 extracted from

Holden, K.M.; Gilbert, M.; Coloe, P.J.; Li, J.; Fry, B.N.
The role of WlaRG, WlaTB and WlaTC in lipooligosaccharide synthesis by Campylobacter jejuni strain 81116 (2012), Microb. Pathog., 52, 344-352 .

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
dTDP-3-dehydro-6-deoxy-D-glucose + D-glutamate	Campylobacter jejuni 81116	the enzyme is involved in lipooligosaccharide synthesis. Campylobacter jejuni produces a range of glycans including lipooligosaccharide, an important virulence factor	dTDP-3-amino-3,6-dideoxy-D-glucose + 2-oxoglutarate	-	?
dTDP-3-dehydro-6-deoxy-galactose + D-glutamate	Campylobacter jejuni 81116	the enzyme is involved in lipooligosaccharide synthesis. Campylobacter jejuni produces a range of glycans including lipooligosaccharide, an important virulence factor	dTDP-3-amino-3,6-dideoxy-D-galactose + 2-oxoglutarate	-	?

Organism

Organism	UniProt	Comment	Textmining
Campylobacter jejuni 81116	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
dTDP-3-dehydro-6-deoxy-D-glucose + D-glutamate	-	Campylobacter jejuni 81116	dTDP-3-amino-3,6-dideoxy-D-glucose + 2-oxoglutarate	-	?
dTDP-3-dehydro-6-deoxy-D-glucose + D-glutamate	the enzyme is involved in lipooligosaccharide synthesis. Campylobacter jejuni produces a range of glycans including lipooligosaccharide, an important virulence factor	Campylobacter jejuni 81116	dTDP-3-amino-3,6-dideoxy-D-glucose + 2-oxoglutarate	-	?
dTDP-3-dehydro-6-deoxy-galactose + D-glutamate	-	Campylobacter jejuni 81116	dTDP-3-amino-3,6-dideoxy-D-galactose + 2-oxoglutarate	-	?
dTDP-3-dehydro-6-deoxy-galactose + D-glutamate	the enzyme is involved in lipooligosaccharide synthesis. Campylobacter jejuni produces a range of glycans including lipooligosaccharide, an important virulence factor	Campylobacter jejuni 81116	dTDP-3-amino-3,6-dideoxy-D-galactose + 2-oxoglutarate	-	?

Synonyms

Synonyms	Comment	Organism
WlaRG	-	Campylobacter jejuni 81116

General Information

General Information	Comment	Organism
malfunction	the wlaRG mutant is non-motile and aflagellate. The wlaRG mutant displays reduced adherence to chicken embryo fibroblasts. The mutant strain is less invasive of human cells than the wild-type strain	Campylobacter jejuni 81116
metabolism	the enzyme is involved in lipooligosaccharide synthesis. Campylobacter jejuni produces a range of glycans including lipooligosaccharide, an important virulence factor	Campylobacter jejuni 81116
physiological function	the enzyme is involved in lipooligosaccharide synthesis. Campylobacter jejuni produces a range of glycans including lipooligosaccharide, an important virulence factor	Campylobacter jejuni 81116

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Release 2023.1 (January 2023)