BRENDA - Enzyme Database
show all sequences of 2.6.1.95

The oxidoreductases LivQ and NeoQ are responsible for the different 6-modifications in the aminoglycosides lividomycin and neomycin

Clausnitzer, D.; Piepersberg, W.; Wehmeier, U.F.; J. Appl. Microbiol. 111, 642-651 (2011)

Data extracted from this reference:

Cloned(Commentary)
Cloned (Commentary)
Organism
expressed in Escherichia coli
Streptomyces fradiae
Organism
Organism
UniProt
Commentary
Textmining
Streptomyces fradiae
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
additional information
NeoB is a bifunctional enzyme that also catalyses the NH2 group transfer at the 6'''-position
719676
Streptomyces fradiae
?
-
-
-
?
neomycin C + 2-oxoglutarate
-
719676
Streptomyces fradiae
6'''-hydroxyneomycin C + L-glutamate
-
-
-
?
Synonyms
Synonyms
Commentary
Organism
neoB
-
Streptomyces fradiae
Cloned(Commentary) (protein specific)
Commentary
Organism
expressed in Escherichia coli
Streptomyces fradiae
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
additional information
NeoB is a bifunctional enzyme that also catalyses the NH2 group transfer at the 6'''-position
719676
Streptomyces fradiae
?
-
-
-
?
neomycin C + 2-oxoglutarate
-
719676
Streptomyces fradiae
6'''-hydroxyneomycin C + L-glutamate
-
-
-
?
Other publictions for EC 2.6.1.95
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
719676
Clausnitzer
The oxidoreductases LivQ and N ...
Streptomyces fradiae
J. Appl. Microbiol.
111
642-651
2011
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719294
Huang
Elaboration of neosamine rings ...
Streptomyces fradiae, Streptomyces fradiae NCIMB 8233
ChemBioChem
8
283-288
2007
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