Cloned (Comment) | Organism |
---|---|
hanging drop vapor diffusion method, high-resolution crystal structures are solved for two native forms and one covalently inhibited form of Salmonella typhimurium ArnB (crystal structure of ArnB aminotransferase with pyridomine 5'-phosphate, crystal structure of ArnB transferase with pyridoxal 5'-phosphate, crystal structure of ArnB aminotransferase with cycloserine and pyridoxal 5'-phosphate) | Salmonella enterica subsp. enterica serovar Typhimurium |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-beta-L-threo-pentapyranos-4-ulose + L-glutamate | Salmonella enterica subsp. enterica serovar Typhimurium | lipid A modification with 4-amino-4-deoxy-L-arabinose confers on certain pathogenic bacteria, such as Salmonella, resistance to cationic antimicrobial peptides, including those derived from the innate immune system ArnB catalysis of amino group transfer from glutamic acid to the 4''-position of a UDP-linked keto-pyranose molecule to form UDP-4-amino-4-deoxy-L-arabinose represents a key step in the lipid A modification pathway | UDP-4-amino-4-deoxy-beta-L-arabinose + 2-oxoglutarate | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Salmonella enterica subsp. enterica serovar Typhimurium |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-beta-L-threo-pentapyranos-4-ulose + L-glutamate | - |
Salmonella enterica subsp. enterica serovar Typhimurium | UDP-4-amino-4-deoxy-beta-L-arabinose + 2-oxoglutarate | - |
r | |
UDP-beta-L-threo-pentapyranos-4-ulose + L-glutamate | lipid A modification with 4-amino-4-deoxy-L-arabinose confers on certain pathogenic bacteria, such as Salmonella, resistance to cationic antimicrobial peptides, including those derived from the innate immune system ArnB catalysis of amino group transfer from glutamic acid to the 4''-position of a UDP-linked keto-pyranose molecule to form UDP-4-amino-4-deoxy-L-arabinose represents a key step in the lipid A modification pathway | Salmonella enterica subsp. enterica serovar Typhimurium | UDP-4-amino-4-deoxy-beta-L-arabinose + 2-oxoglutarate | - |
r |