Literature summary for 2.6.1.83 extracted from

Sadhasivam, A.; Vetrivel, U.
Identification of potential drugs targeting L,L-diaminopimelate aminotransferase of Chlamydia trachomatis an integrative pharmacoinformatics approach (2019), J. Cell. Biochem., 120, 2271-2288 .

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Application

Application	Comment	Organism
drug development	the enzyme is a target for drug development	Chlamydia trachomatis

Inhibitors

Inhibitors	Comment	Organism	Structure
1,3-bis((7-chloro-4-quinolinyl)amino)-2-propanol	NSC_5485, potential drug candidate that can inhibit the enzymatic activity of enzyme CtDAP-AT	Chlamydia trachomatis
additional information	high-throughput virtual screening for potential enzyme inhibitors using the optimized and corrected PLP-bound L,Ldiaminopimelate aminotransferase structure based on the crystal structure, PDB ID 3ASB. Comparative molecular dynamics simulation studies of enzyme CtDAP-AT in apoform and in complex with potential inhibitors, intermolecular interaction profiling of the compounds in complex with CtDAP-AT	Chlamydia trachomatis

Organism

Organism	UniProt	Comment	Textmining
Chlamydia trachomatis	-	-	-

Synonyms

Synonyms	Comment	Organism
CtDAP-AT	-	Chlamydia trachomatis

Cofactor

Cofactor	Comment	Organism	Structure
pyridoxal 5'-phosphate	PLP, dependent on	Chlamydia trachomatis

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Release 2023.1 (January 2023)