Application | Comment | Organism |
---|---|---|
drug development | the LL-diaminopimelate aminotransferase (DapL) pathway is an attractive pipeline to identify targets for the development of antibiotic compounds | Verrucomicrobium spinosum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Barbiturate | binding structure model | Verrucomicrobium spinosum | |
hydrazide | binding structure model | Verrucomicrobium spinosum | |
additional information | rhodanine, barbiturate, hydrazide, and thiobarbiturate associations with VsDapL are supported by molecular dynamics simulations, docking study, overview | Verrucomicrobium spinosum | |
rhodanine | binding structure model | Verrucomicrobium spinosum | |
thiobarbiturate | binding structure model | Verrucomicrobium spinosum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
LL-2,6-diaminoheptanedioate + 2-oxoglutarate | Verrucomicrobium spinosum | - |
(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Verrucomicrobium spinosum | A0A6P3CW87 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
LL-2,6-diaminoheptanedioate + 2-oxoglutarate | - |
Verrucomicrobium spinosum | (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O | - |
r |
Subunits | Comment | Organism |
---|---|---|
homodimer | - |
Verrucomicrobium spinosum |
Synonyms | Comment | Organism |
---|---|---|
DapL | - |
Verrucomicrobium spinosum |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Verrucomicrobium spinosum |
General Information | Comment | Organism |
---|---|---|
metabolism | the LL-diaminopimelate aminotransferase (DapL) pathway is a variant of the lysine biosynthetic pathway, overview | Verrucomicrobium spinosum |
additional information | comparative molecular dynamics simulations, ligand docking study, sequence comaprisons and three-dimensional homology modelling, active site structure, detailed overview. Key conserved active site residues are identified as I43, G44, Y74, E77, K111, Y134, N189, K251, N294, and R390 | Verrucomicrobium spinosum |
physiological function | DapL is a homodimer that catalyzes the conversion of tetrahydrodipicolinate to LL-diaminopimelate in a single transamination reaction. The penultimate and ultimate products of the lysine biosynthesis pathway, meso-diaminopimelate and lysine, are key components of the Gram-negative and Gram-positive bacterial peptidoglycan cell wall | Verrucomicrobium spinosum |