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Literature summary for 2.6.1.81 extracted from

  • Schneider, B.L.; Kiupakis, A.K.; Reitzer, L.J.
    Arginine catabolism and the arginine succinyltransferase pathway in Escherichia coli (1998), J. Bacteriol., 180, 4278-4286.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.6.1.81

Activating Compound

Activating Compound Comment Organism Structure
additional information arginine induces the enzyme in cells grown on glucose and arginine Escherichia coli K-12
additional information arginine induces the enzyme, glutamine slightly induces the enzyme Klebsiella aerogenes

Protein Variants

Protein Variants Comment Organism
additional information construction of disruption and of overexpression mutants showing reduced and increased enzyme activities compared to the wild-type, respectively Escherichia coli K-12

Inhibitors

Inhibitors Comment Organism Structure
additional information NH4+ suppresses the enzyme expression, utilization of carbon sources other than glucose that are frequently involved in catabolic repression Escherichia coli K-12
additional information NH4+ suppresses the enzyme expression, utilization of carbon sources other than glucose frequently involved catabolic repression Klebsiella aerogenes

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N2-succinyl-L-ornithine + 2-oxoglutarate Klebsiella aerogenes the enzyme is involved in the catabolic arginine succinyltransferase, AST, pathway, arginine catabolism overview, regulation of the enzyme activity depends on the ability to utilize arginine as carbon and nirogen source, other nutrients influence the enzyme expression, overview N2-succinyl-L-glutamate 5-semialdehyde + L-glutamate
-
 ?
N2-succinyl-L-ornithine + 2-oxoglutarate Escherichia coli K-12 the enzyme is involved in the catabolic arginine succinyltransferase, AST, pathway, arginine catabolism overview, regulation of the enzyme activity depends on the ability to utilize arginine as carbon and nitrogen source, other nutrients influence the enzyme expression, overview N2-succinyl-L-glutamate 5-semialdehyde + L-glutamate
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli K-12
-
-
-
Klebsiella aerogenes
-
-
-

Purification (Commentary)

Purification (Comment) Organism
from strain W3110, by ammonium sulfate fractionation, ion exchange chromatography, gel filtration, and hydrophobic interaction chromatography Escherichia coli K-12

Source Tissue

Source Tissue Comment Organism Textmining
culture condition:arginine-grown cell
-
 Klebsiella aerogenes
-
culture condition:glucose/arginine-grown cell
-
 Escherichia coli K-12
-
additional information Escherichia coli is not able to grow on arginine as sole carbon, energy, and nitrogen source Escherichia coli K-12
-
additional information Klebsiella aerogenes is able to grow on arginine as sole carbon, energy, and nitrogen source Klebsiella aerogenes
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N2-succinyl-L-ornithine + 2-oxoglutarate
-
 Klebsiella aerogenes N2-succinyl-L-glutamate 5-semialdehyde + L-glutamate
-
 ?
N2-succinyl-L-ornithine + 2-oxoglutarate
-
 Escherichia coli K-12 N2-succinyl-L-glutamate 5-semialdehyde + L-glutamate
-
 ?
N2-succinyl-L-ornithine + 2-oxoglutarate the enzyme is involved in the catabolic arginine succinyltransferase, AST, pathway, arginine catabolism overview, regulation of the enzyme activity depends on the ability to utilize arginine as carbon and nirogen source, other nutrients influence the enzyme expression, overview Klebsiella aerogenes N2-succinyl-L-glutamate 5-semialdehyde + L-glutamate
-
 ?
N2-succinyl-L-ornithine + 2-oxoglutarate the enzyme is involved in the catabolic arginine succinyltransferase, AST, pathway, arginine catabolism overview, regulation of the enzyme activity depends on the ability to utilize arginine as carbon and nitrogen source, other nutrients influence the enzyme expression, overview Escherichia coli K-12 N2-succinyl-L-glutamate 5-semialdehyde + L-glutamate
-
 ?

Synonyms

Synonyms Comment Organism
SOT
-
 Klebsiella aerogenes
SOT
-
 Escherichia coli K-12
succinylornithine aminotransferase
-
 Klebsiella aerogenes
succinylornithine aminotransferase
-
 Escherichia coli K-12

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Klebsiella aerogenes
pyridoxal 5'-phosphate
-
 Escherichia coli K-12