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Literature summary for 2.6.1.7 extracted from
- The synthesis of kynurenic acid in mammals an updated kynurenine aminotransferase structural KATalogue (2019), Front. Mol. Biosci., 6, 7-7 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (3R)-3-amino-6-benzyl-1-hydroxy-7-methoxy-3,4-dihydroquinolin-2(1H)-one | irreversible inhibitor | Mus musculus |  |
| (5S)-5-amino-7-hydroxy-2-phenyl-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-b]pyridin-6-one | irreversible inhibitor | Mus musculus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q16773 | - |
- |
| Homo sapiens | Q8N5Z0 | - |
- |
| Mus musculus | P05202 | - |
- |
| Mus musculus | Q71RI9 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| astrocyte | - |
Homo sapiens | - |
| astrocyte | - |
Mus musculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.3 | - |
with L-kynurenine as substrate, pH and temperature not specified in the publication | Mus musculus |
| 0.45 | - |
with 3-hydroxy-DL-kynurenine as substrate, pH and temperature not specified in the publication | Mus musculus |
| 0.5 | - |
with 3-hydroxy-DL-kynurenine as substrate, pH and temperature not specified in the publication | Mus musculus |
| 0.65 | - |
with 3-hydroxy-DL-kynurenine as substrate, pH and temperature not specified in the publication | Homo sapiens |
| 0.85 | - |
with L-kynurenine as substrate, pH and temperature not specified in the publication | Homo sapiens |
| 2.5 | - |
with L-kynurenine as substrate, pH and temperature not specified in the publication | Mus musculus |
| 3.9 | - |
with L-kynurenine as substrate, pH and temperature not specified in the publication | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-hydroxy-DL-kynurenine + 2-oxoglutarate | - |
Homo sapiens | xanthurenic acid + L-glutamate + H2O | - |
? | |
| 3-hydroxy-DL-kynurenine + 2-oxoglutarate | - |
Mus musculus | xanthurenic acid + L-glutamate + H2O | - |
? | |
| L-kynurenine + 2-oxoglutarate | - |
Homo sapiens | kynurenic acid + L-glutamate + H2O | - |
? | |
| L-kynurenine + 2-oxoglutarate | - |
Mus musculus | kynurenic acid + L-glutamate + H2O | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homodimer | - |
Homo sapiens |
| homodimer | - |
Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| KAT I | isoform | Homo sapiens |
| KAT II | isoform | Homo sapiens |
| KAT III | isoform | Mus musculus |
| KAT IV | isoform | Mus musculus |
| kynurenine aminotransferase | - |
Homo sapiens |
| kynurenine aminotransferase | - |
Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Homo sapiens | |
| pyridoxal 5'-phosphate | - |
Mus musculus | |
kcat/KM [mM/s]
| kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.45 | - |
3-hydroxy-DL-kynurenine | pH and temperature not specified in the publication | Homo sapiens | |
| 0.713 | - |
L-kynurenine | pH and temperature not specified in the publication | Homo sapiens | |
| 1.53 | - |
L-kynurenine | pH and temperature not specified in the publication | Mus musculus | |
| 2.1 | - |
L-kynurenine | pH and temperature not specified in the publication | Homo sapiens | |
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